Artikel
Allergy-associated receptor eotaxin-2 and ist receptor CCR-3 : differentiation between normal and polypous nasal mucosa
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Veröffentlicht: | 22. September 2005 |
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Gliederung
Text
Chronic-polypous sinusitis is often associated with an eosinophilia of nasal tissue. CC-chemokines like RANTES, MCP or eotaxin are well known as chemotactic mediators of eosinophilic granulocytes. All of the use CCR-3 as their receptor. The aim of this study was to differentiate the mediator- and receptor-expression of normal and polypous nasal mucosa. Biopsies of nasal turbinates and polypous tissue were immunhistochemical characterised using anti-eotaxin-2- and anti-CCR-3-antibodies. In epithelial and endothelial cells there was only a low evidence of eotaxin-2, whereas there was a high evidence in polypous tissue. CCR-3-positive cells were rarely verified in nasal polypous mucosa. Positive cells were characterised as eosinophilic granulocytes and lymphocytes.
Endothelial and epithelial cells are a possible source of eotaxin-2 in normal nasal mucosa and in nasal polyps. These allergen-activated cells synthesize chemokines, followed by a expression of CCR-3. CCR-3-antagonists could be a therapeutic possibility in inflammatory and allergic diseases in future.