Artikel
Coffee consumption in association with cardiovascular diseases in individuals with prediabetes and type 2 diabetes: data from a Swedish cohort
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Autoren
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Janett Barbaresko
- Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany
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Hrafnhildur Gudjonsdottir
- Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden
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Anton Lager
- Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden
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Boel Brynedal
- Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden
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Sabrina Schlesinger
- Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, München-Neuherberg, Germany
| Veröffentlicht: | 6. September 2024 |
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Gliederung
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Introduction: Individuals with prediabetes and type 2 diabetes (T2D) are at an increased risk for several comorbidities including cardiovascular diseases (CVD). Coffee consumption has been shown to be inversely associated with T2D incidence, however, evidence is scarce with respect to diabetes complications. The aim of our study was to investigate the prospective association of coffee consumption and cardiovascular diseases in a Swedish population with prediabetes and type 2 diabetes.
Methods: We used data from the Stockholm Diabetes Prevention Programme (SDPP). An oral glucose tolerance test was used to identify individuals with prediabetes or T2D according to the criteria from the American Diabetes Association. In addition, newly diagnosed T2D was identified by register data. Frequency of coffee consumption was assessed by a questionnaire. CVD events (including ischemic heart disease, heart failure, peripheral artery disease and cerebrovascular disease) during follow-up were obtained from the register. Multivariable adjusted Cox regression was conducted to estimate hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age, sex, education, physical activity, smoking, alcohol consumption and diabetes status.
Results: We included 1,356 participants (596 women, 760 men) with prediabetes (n=1,157) or T2D (n=199) with a mean age of 54 years at baseline. During a median follow-up time of 18.5 years, 427 CVD events occurred. Compared to less than 1 cup/day, consumption of 1-2 cups of coffee/day was associated with a reduced relative risk of CVD of 0.67 (95% CI: 0.46, 0.97), 3-4 cups/day with 0.76 (95% CI: 0.54, 1.08), and 5 or more cups/day with 0.80 (95% CI: 0.55, 1.18). Stratified by diabetes status, the consumption of 5 or more cups of coffee/day was associated with a HR of 0.44 (95% CI: 0.13, 1.48) in individuals with T2D and 0.96 (95% CI: 0.64, 1.49) in individuals with prediabetes, compared to the consumption of less than 1 cup/day.
Conclusion: The consumption of coffee was inversely associated with CVD in individuals with prediabetes and T2D. There was an indication for a stronger association in individuals with T2D.
The authors declare that they have no competing interests.
The authors declare that a positive ethics committee vote has been obtained.
