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65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS)

06.09. - 09.09.2020, Berlin (online conference)

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Physical activity and risk of Alzheimer's disease: a two-sample Mendelian randomization study

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  • Sebastian-Edgar Baumeister - Lehrstuhl für Epidemiologie der LMU München am UNIKA-T Augsburg, Augsburg, Germany
  • André Karch - Westfälische Wilhelms-Universität Münster, Münster, Germany
  • Martin Bahls - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
  • Alexander Teumer - Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
  • Michael Leitzmann - Universität Regensburg, Regensburg, Germany
  • Hansjörg Baurecht - Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie. 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS). Berlin, 06.-09.09.2020. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocAbstr. 147

doi: 10.3205/20gmds221, urn:nbn:de:0183-20gmds2211

Veröffentlicht: 26. Februar 2021

© 2021 Baumeister et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

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Text

Background: Evidence from observational studies for the effect of physical activity on the risk of Alzheimer's disease (AD) is inconclusive. We performed a two-sample Mendelian randomization analysis to examine whether physical activity is protective for AD.

Methods: Summary data of genome-wide association studies on accelerometer-measured physical activity and AD were used. The primary study population included 21,982 AD cases and 41,944 cognitively normal controls. Eight single nucleotide polymorphisms (SNPs) known at P<5x10-8 to be associated with ‘average accelerations’ and eight SNPs associated at P<5x10-7 with vigorous physical activity (‘fraction of accelerations >425 milli-gravities’) served as instrumental variables.

Results: There was no association between genetically predicted ‘average accelerations’ with the risk of AD (inverse variance weighted odds ratio [OR] per standard deviation (SD) increment: 1.03, 95% confidence interval: 0.97-1.10, P=0.332). Genetic liability for ‘fraction of accelerations >425 milli-gravities’ was unrelated to AD risk.

Conclusion: The present study does not support a causal association between physical activity and risk of AD.

The authors declare that they have no competing interests.

The authors declare that an ethics committee vote is not required.