Artikel
Overweight and incidence of cancer: results of a large cohort study with more than 145,000 adults in Austria
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Veröffentlicht: | 8. September 2005 |
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To investigate the relation of overweight and obesity with the incidence of cancer a population-based cohort of more than 145,000 Austrian adults (67,447 men and 78,484 women) was followed over an average of 10.9 years. Incident cancers (n=6241) were documented by the state cancer registry. Cox proportional-hazards models were calculated adjusting for smoking and occupational group. In men, increases in relative body weight were associated with colon cancer (hazard rate ratio (HR) 2.48; 95% confidence interval (CI): 1.15, 5.39 for body-mass index (BMI) ≥ 35 kg/m2) and pancreatic cancer (HR 2.34, 95% CI: 1.17, 4.66 for BMI > 30 kg/m2) compared to participants with normal weight (BMI 18.5 to 24.9 kg/m2). In women, there was a weak positive association between increasing BMI and all cancers combined, and strong associations with non-Hodgkin’s lymphomas (HR 2.86, 95% CI: 1.49, 5.49 for BMI ≥ 30 kg/m2) and cancers of the uterine corpus (HR 3.93, 95% CI: 2.35, 6.56 for BMI ≥ 35 kg/m2). Incidence of breast cancer was positively associated with high BMI after age 65 years. These findings provide further evidence that overweight is associated with the incidence of several types of cancer in men and women.