gms | German Medical Science

G-I-N Conference 2012

Guidelines International Network

22.08 - 25.08.2012, Berlin

The GRADE approach to assessing the quality of a body of evidence and the strength of recommendations: Diagnosis

Meeting Abstract

  • H. Schünemann - McMaster University, Hamilton, Canada
  • R. Mustafa - McMaster University, Hamilton, Canada
  • J. Brozek - McMaster University, Hamilton, Canada
  • M. Langendam - University of Amsterdam, Amsterdam, The Netherlands

Guidelines International Network. G-I-N Conference 2012. Berlin, 22.-25.08.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. DocWS10

doi: 10.3205/12gin031, urn:nbn:de:0183-12gin0310

Veröffentlicht: 10. Juli 2012

© 2012 Schünemann et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen ( Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.



Background: Developing recommendation about diagnostic tests is particularly challenging. The GRADE working group has suggested an approach to grading the quality of evidence and develop recommendations for questions of diagnostic accuracy that has been used in several guidelines. Using this approach, cross sectional or cohort studies can provide high quality evidence of test accuracy if they are linked to direct information about patient-important outcomes. However, test accuracy is a surrogate for patient-important outcomes, so that these studies often provide low quality evidence for recommendations about diagnostic tests, even when the studies do not have serious limitations. This workshop will introduce this approach and evaluate different formats of Summary of Findings Tables based on examples and hands-on exercises.

Objectives: To learn how to create a Summary of Findings (SoF) Table for diagnostic questions and how to move to recommendations.

Description: This workshop provides a brief overview of GRADE for diagnostic questions. Each group will then take a systematic review and start to create a SoF Table. During the small group work, participants will discuss the challenges and advantages of the approach. Participants will then apply these concepts in small groups to create a sample SoF and develop a recommendation; they will also participate in feedback sessions that will help to enhance the work and provide opportunities for collaboration.