gms | German Medical Science

27. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie (GAA)

Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie

26.11.2020, digital

Safety of contrast enhanced ultrasound in children and adolescents

Meeting Abstract

Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie e.V. (GAA). 27. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie. sine loco [digital], 26.-26.11.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. Doc20gaa05

doi: 10.3205/20gaa05, urn:nbn:de:0183-20gaa055

Veröffentlicht: 23. November 2020

© 2020 Seelbach et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Background: The application of ultrasound contrast agents (UCA) in children is hampered by only few data about safety, the acceptance of UCA studies and the lack of approval in most indications. The aim of this questionnaire was to evaluate the safety of the CEUS and ce-VUS in children and adolescence and to receive data about parents’ acceptance of intravesical and intravenous application of SonoVue®.

Materials and methods: Within a one-year period, the parents of 56 children (f/m=32/24; mean age 3.1 years; range 3 weeks – 15.9 years) with ce-VUS and of 30 children (f/m=15/15; mean age 10.5 years; range 2 months – 17.7 years) with CEUS could agree to be included in this prospective study. A standardized telephone survey about the acceptance of the parents during and after the procedure as well as the adverse events (AE) was conducted at the earliest three days after the examination.

Results: The parents would agree with the use of both ce-VUS and CEUS as a diagnostic tool again in 96% (54/56) or 100% (30/30) of the cases, respectively. 92.9% (52/56) would prefer ce-VUS rather than voiding cystourethrography. In addition, 83.3% (25/30) would prefer CEUS rather than computed tomography and 73.3% (22/30) would prefer CEUS rather than magnetic resonance imaging. AE after the ce-VUS were reported in 3.6% (2/56; skin rash, mild fever) and in 3.3% after VEUS (1/30; vomiting). AE were subacute and self-limited.

Conclusion: The vast majority of parents prefer ce-VUS and CEUS instead of voiding cystourethrography, computed tomography or magnetic resonance imaging because of agents safety and diagnostic accuracy.