gms | German Medical Science

23. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie (GAA)

Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie

24.11. - 25.11.2016, Bochum

Drug costs depending on the weekday of birth for births 1920–1929

Meeting Abstract

Suche in Medline nach

Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie e.V. (GAA). 23. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie. Bochum, 24.-25.11.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. Doc16gaa11

doi: 10.3205/16gaa11, urn:nbn:de:0183-16gaa113

Veröffentlicht: 23. November 2016

© 2016 Schuster et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Background: We will consider if there are long term influences of circumstances near the birth on the health status. On the one hand, there is a weekly rhythm. Considering birth data between 1920 till 1929 we have to take into account that the social conditions and the medical care during these times differed much from current conditions. In order to measure the health status of older persons we use drug costs. On the other hand, there are seasonal influences. This consideration is more common, we will state the respective results using our data base in a later paper. In the discussion of seasonal influences one has to take into account shifts due to holidays, especially for long term drug prescriptions (cf. [10]). The first discussion of the influence of the weekday of birth on a large data basis was given in [6], [8] using birth data of the seventies, our data focus on some decades before. Furthermore the number of births with respect to the weekday differs much from the present-day pattern. Related backgrounds are discussed in [1], [2], [3], [4], [5], [7], [9], [11], [12].

Materials and Methods: We use health and care insurance data from a German federal state. With respect to sufficient statistical significance in the care insurance field we can go as far back as people born in 1905 by using data from 1998 till 2006, in the health insurance data from 2006 one can track back until 1920. Although we only need aggregated data, such data with a weekday resolution are rarely available. For calculations we use Microsoft Excel and Mathematica from Wolfram Research.

Results: The difference of the drug costs with respect to the weekday of birth and the average weekly costs shows the same pattern in both birth groups 1920-1924 and 1925-1929 for every weekday (cf. Figure 1 [Fig. 1]). The largest positive cost differences (approx. +2%) we get on Saturdays. The lowest costs are found on Thursdays (approx. - 2%). The other days with increased costs are Monday and Friday, days with lower drug costs are Tuesday, Wednesday and Sunday. Drug costs increase in average by 1.5% per year. With respect to the care insurance data there are increased birth rates for people born 1905-1929 on weekends (cf. Figure 2 [Fig. 2]) and reduced birthrates on Tuesdays and Wednesdays. The other days show no observable pattern. If we use the health insurance data, we get almost the same results with some shift from Saturday to Friday (cf. Figure 3 [Fig. 3]). We also can use a weighted combination of health and care insurance data (cf. Figure 4 [Fig. 4]) ignoring the fact that a simple combination of the datasets would count especially younger individuals twice. There is a long term shift (100 years) from Sunday to Tuesday and Wednesday births (cf. Figure 5 [Fig. 5]) using 5 year birth data smoothing.

Conclusion: In order to consider the time between birth and measurements using data of health and care insurance the following statements and guesses can be made regarding the results. In scenario 1 more births measured in insurance data can be caused by more real births in the considered time 1915-1930. That can be due to different conception/fertilization possibilities depending on the day of the week. A bias may be caused by migration. In scenario 2 the day of birth may cause different survival expectancies in the critical first three days after birth and the related health conditions during these days. So here we take a look at drug costs in dependence of the day of birth. As we already stated, drug costs increase in the mean by 1.5% per year between the considered two age groups. As a modelling consideration one can use drug costs as a proxy for biological age, comparing it with chronological age. Due to the considered age dependent drug cost increase we can suspect a strong connection to the residual life expectancy. Thursday births around 90 years ago have a one year higher residual life expectancy. Saturday births have a one year lower residual life expectancy, Sunday births have 4 months higher residual life expectancy. In contrast to the situation stated in [6] lower perinatal mortality rates at weekends can be caused by the fact that quality of care is higher due to family background. In those times specialist obstetric services have been less common compared to later decades. It is quite important, that the psycho-social near birth circumstances 90 years ago may induce significant differences today.


References

1.
Kibele EU, Jasilionis D, Shkolnikov VM. Widening socioeconomic differences in mortality among men aged 65 years and older in Germany. J Epidemiol Community Health. 2013 May;67(5):453-7. DOI: 10.1136/jech-2012-201761 Externer Link
2.
Klein T, Schneider S, Löwel H. Bildung und Mortalität. Die Bedeutung gesundheitsrelevanter Aspekte des Lebensstils. Zeitschrift für Soziologie. 2001;30(5):384–400. DOI: 10.1515/zfsoz-2001-0504 Externer Link
3.
Klein T, Unger R. Aktive Lebenserwartung in Deutschland und in den USA. Kohortenbezogene Analysen auf Basis des Sozio-ökonomischen Panel und der Panel Study of Income Dynamics [Active life expectancy in Germany and in the United States. A cohort analysis based on the "German Socio-Economic Panel" (GSOEP) and the "Panel Study of Income Dynamics" (PSID)]. Z Gerontol Geriatr. 2002 Dec;35(6):528-39. DOI: 10.1007/s00391-002-0127-0 Externer Link
4.
Lampert T, Kroll LE. Soziale Unterschiede in der Mortalität und Lebenserwartung. Berlin: Robert Koch-Institut; 2014. GBE kompakt; 5(2)/2014.
5.
Ma J, Xu J, Anderson RN, Jemal A. Widening educational disparities in premature death rates in twenty six states in the United States, 1993-2007. PLoS ONE. 2012;7(7):e41560. DOI: 10.1371/journal.pone.0041560 Externer Link
6.
MacFarlane A. Variations in number of births and perinatal mortality by day of week in England and Wales. Br Med J. 1978 Dec;2(6153):1670-3.
7.
Mackenbach J. Health inequalities: Europe in Profile. An independent expert report commissioned by the UK Presidency of the EU. London: Department of Health; 2006.
8.
Mathers CD. Births and perinatal deaths in Australia: variations by day of week. J Epidemiol Community Health. 1983 Mar;37(1):57-62. DOI: 10.1136/jech.37.1.57 Externer Link
9.
Schnell R, Trappmann M. Konsequenzen der Panelmortalität im SOEP für Schätzungen der Lebenserwartung. Arbeitspapier 2/2006. Mannheim, Konstanz: Zentrum für Quantitative Methoden und Surveyforschung; 2006.
10.
Schuster R, Emcke T. Unterjährige Schwankungen bei den Arzneimittelverschreibungen und bei der Anzahl der Patienten pro Arzt: eine Baseline für den vertragsärztlichen Bereich. In: HEC 2016: Health – Exploring Complexity. Joint Conference of GMDS, DGEpi, IEA-EEF, EFMI. München, 28.08.-02.09.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocAbstr. 519. DOI: 10.3205/16gmds087 Externer Link
11.
Steingrímsdóttir OA, Næss Ø, Moe JO, Grøholt EK, Thelle DS, Strand BH, Bævre K. Trends in life expectancy by education in Norway 1961-2009. Eur J Epidemiol. 2012 Mar;27(3):163-71. DOI: 10.1007/s10654-012-9663-0 Externer Link
12.
Wolf IK, Knopf H, Scheidt-Nave C, Kurth BM. Möglichkeiten und Grenzen retrospektiver Todesursachenrecherchen im Rahmen bundesweiter epidemiologischer Studien [Possibilites and limitations of retrospective research on cause of death within the framework of a nationwide epidemiological study]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012 Mar;55(3):431-5. DOI: 10.1007/s00103-012-1443-1 Externer Link