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20. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie (GAA)

Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie

05.12. - 06.12.2013, Düsseldorf

Secondary-data analysis of hospital and ambulatory prescriptions of antibiotics in Dresden

Sekundärdaten-basierte Analyse der ambulanten und stationären Antibiotikaverordnungen in Dresden

Meeting Abstract

  • corresponding author presenting/speaker Viktoria Mühlbauer - Institut für Klinische Pharmakologie, Technische Universität Dresden, Dresden, Germany
  • Luise Hutka - Professur für Geoinformationssysteme, Technische Universität Dresden, Dresden, Germany
  • Daniel Kadner - Professur für Geoinformationssysteme, Technische Universität Dresden, Dresden, Germany
  • Lars Bernard - Professur für Geoinformationssysteme, Technische Universität Dresden, Dresden, Germany
  • Wilhelm Kirch - Institut für Klinische Pharmakologie, Technische Universität Dresden, Dresden, Germany

Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie e.V. (GAA). 20. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie. Düsseldorf, 05.-06.12.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. Doc13gaa35

doi: 10.3205/13gaa35, urn:nbn:de:0183-13gaa353

Veröffentlicht: 25. November 2013

© 2013 Mühlbauer et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background: Pharmaceutical consumption and consequently their input into the aquatic environment after passing the sewer system and sewage treatment plants is inevitable and of increasing concern. Especially antibiotics released in the environment pose a potential risk to promote resistant bacteria. The project ANTI-Resist therefore analyzes the antibiotic input and bacterial resistances in the sewer system and the waste water treatment plant in an urban context focusing the city of Dresden, Germany.

Materials and Methods: To find out which antibiotics play an important role, a secondary-data analysis was conducted. Prescriptions from a health insurance company that covers 40% of all inhabitants in Dresden were evaluated. Additionally, data from three hospitals providing ~2.800 beds were analyzed. Prescription data from 2005–2011 was available on a weekly basis for ambulatory data and per month or year for hospital data. Several antibiotics could be identified that play an important role either in the ambulatory or stationary setting. Analyses focus 2009–2010.

Results: As a result, 13 antibiotics were identified representing 80% of all ambulatory antibiotic prescriptions. For some antibiotics, especially macrolides, seasonal trends could be discovered and correlated with data on pulmonary infections. Several quarters with high prescription rates could be identified and correlated with socio-demographic data like the population density and rate of unemployment. All results can be found on the ANTI-Resist geoportal http://antiresist.dyndns.org/

Conclusion: The aim of the project ANTI-Resist is to identify antibiotics and quarters that play an important role for the development of resistant bacteria. Finally, the results will be taken to create a rapid-alert system to predict critical situations in the sewer system.

Acknowledgment: The project ANTI-Resist (02WRS1272A) is funded by the German Federal Ministry of Education and Research within the initiative Risk Management of Emerging Compounds and Pathogens in the Water Cycle (RISKWa).


References

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Kümmerer K. The presence of pharmaceuticals in the environment due to human use--present knowledge and future challenges. J Environ Manage. 2009 Jun;90(8):2354-66. DOI: 10.1016/j.jenvman.2009.01.023 Externer Link
2.
Baquero F, Martínez JL, Cantón R. Antibiotics and antibiotic resistance in water environments. Curr Opin Biotechnol. 2008 Jun;19(3):260-5. DOI: 10.1016/j.copbio.2008.05.006 Externer Link