gms | German Medical Science

The ABC Conference: Algae Bioactive Compounds – from research to innovation

The project is funded by Interreg Deutschland-Danmark with means from the European Regional Development Fund.

25. - 26.08.2020, Kiel, Germany (online conference)

Conventional and sustainable bioprocesses for the extraction of antiherpetic oligo- and polysaccharides from the red seaweeds

Meeting Abstract

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  • presenting/speaker Nathalie Bourgougnon - Univ. Bretagne Sud, Laboratoire de Biotechnologie et Chimie Marines, Institut Universitaire Européen de la Mer, Vannes, France

The FucoSan consortium. The ABC Conference: Algae Bioactive Compounds – from research to innovation. Kiel, 25.-26.08.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. Doc20fucosan01

doi: 10.3205/20fucosan01, urn:nbn:de:0183-20fucosan017

Veröffentlicht: 7. Oktober 2020

© 2020 Bourgougnon.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe



Despite the successes, understanding of viral proliferation cycle, comprehensive studies for suitable vaccines and treatments against viral infections over the past half of century, still several infections, such as Human Immunodeficiency Virus (HIV) or Hepatitis C Virus (HCV), afflict a substantial proportion of the world populations in all generations. There is no definite vaccine against numerous prevalent viral infections, including Herpes Simplex viruses (HSV-1 and HSV-2) or Dengue virus. Moreover, drug resistance to available antiviral agents by different viruses has always been a serious impediment to treatment of viral infections, stimulating the search for new efficient molecules.

Carrageenan is a generic name for a family of natural, water-soluble, sulphated galactans that are isolated from Rhodophyta and exploited on commercial scale. These phycocolloids exhibit high viscosity, and stabilizing, emulsifying and unique gelling properties, used in the pharmaceutical, chemical and food industries. They were also shown to be potent and selective inhibitors of several enveloped viruses’ replication in vitro. Their modes of action have been attributed to the blockage of some early stages of the virus replication cycle.

The carrageenophyte Solieria chordalis (C. Agardh) J.Agardh (Gigartinales, Solieriaceae) has been observed in the Gulf of Morbihan (France) since 2005 and in the Sarzeau peninsula (Morbihan, France) where strandings have become more abundant between July and October. S. chordalis is a real economic and environmental burden due to its littoral anarchic proliferation. The processing of this raw material is little developed and provides little added value whereas it constitutes a biomass, potentially rich in highly bioactive polysaccharides that could represent useful avenues for the development of new functional ingredients in pharmaceutical industries.

The aim of this conference is then to compare and discuss the use of sustainable bioprocesses for extracting and purifying antiviral polysaccharides from Solieria chordalis. To improve the extraction conditions of polysaccharides, we propose to use Microwave-Assisted extraction (MAE) and Enzyme-Assisted Extraction (EAE) techniques in comparison with the conventional Hot Water Extraction (HWE) at high temperature followed by filtration and precipitation with alcohol. Antiviral activity from oligo- and polysaccharides was evaluated in mammalian cell lines, infected by HSV-1 in vitro.