Artikel
Exudative age-related macular degeneration in fluorescein angiograms and polarimetry
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Autoren
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A. Weber
- Schepens Eye Research Institute, Harvard Med. School, Boston/USA; Augenklinik des Universitätsklinikum Aachen
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A.E. Elsner
- Schepens Eye Research Institute, Harvard Med. School, Boston/USA
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M.C. Cheney
- Schepens Eye Research Institute, Harvard Med. School, Boston/USA
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M. Miura
- Tokyo Med. Univ., Inashiki/J
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P. Salvetti
- Clinique a Pare, Centre Nord Vision, Lille/F
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A. Remky
- Augenklinik des Universitätsklinikum Aachen
| Veröffentlicht: | 22. September 2004 |
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Gliederung
Text
Objective
To compare exudative lesions due to age-related macular degeneration (AMD) in fluorescein angiograms (FA) and novel types of polarimetry images.
Methods
Images from 18 eyes with exudative AMD were graded by three experienced, blinded graders for the detection and localization of lesions, such as choroidal neovascularization (CNV) and leakage. Images included 3 polarimetry images (depolarized, birefringence and average image) and an early and late phase FA. Lesion didn't exceed 15 deg of size and the chosen FA's were of good quality. The polarimetry images were computed from raw data obtained by the GDx (LDT).
Results
Graders detected CNV most confidently in the early phase FA and graded it significantly different from the next best image type, the average image (p=0.0017). Leakage was most confidently detected in the average image. The next best image type, the FA, wasn't graded significantly different from the average image (p=0.071), nor from the depolarized image (p=0.599). The birefringence was least favored for detection of both lesion types. The total area of the circled regions was higher for fluid than for CNV in all images; in the FA fluid area was 4.8 times larger than the CNV area, in the average image 6.8 times and in the depolarized image 3.5.
Conclusions
Experienced clinicians are most likely to detect CNV in early phase FA, when this is of good quality, but for the detection of the fluid component a noninvasive method was more effective. When the entire lesion was considered (CNV and leakage), a combination of different polarimetry information might help to evaluate an exudative lesion with similar precision as in the FA, but without pupil dilation and dye injection.
