gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Structural changes of the sclera-connective tissue in keratoconus and pellucid marginal corneal degeneration

Meeting Abstract

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  • corresponding author E. V. Ivanovskaya - The Filatov Institute of Eye Diseases and Tissue Therapy, Odessa/UA
  • N. E. Dumbrova - The Filatov Institute of Eye Diseases and Tissue Therapy, Odessa/UA

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogP 019

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Veröffentlicht: 22. September 2004

© 2004 Ivanovskaya et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

Genetically conditioned progressing cornea ectasia (keratoconus, pellucid marginal degeneration) characterized by changes elastic facilities cornea at the expense of biochemical, morphological disturbances. It is known that elastic facilities of the corneal and sclera mutually connected. The aim is to investigate the specularities of the sclera connective tissue at these diseases electron microscopically.

Methods

Transmission electron microscopy were performed in 5 scleral discs in diameter 2 mm removed by posterior sclerectomy in 4 patients (4 eyes) with keratoconus III-IV degree (classification by Amsler) and 1 patient (1 eye) with pellucid marginal corneal degeneration. One patient had Down's syndrome.

Results

There were established pathological changes of collagenic structures of the sclera connective tissue by the type observed in high myopia - peculiarly changed collagenic complexes (splitting into subfibrills, their granular decomposition as well as formation of periodic "notches" fibrils, "stepping" structurs). Primary structural changes analogic to the above mentioned revealed by myopia in anterior section of sclera that says about their primary character. In Down's syndrome the eye with keratoconus had mainly typical dystrophy of the sclera connective tissue caused by inflam-matory processes, with may be masking primary changes of collagenic structures.

Conclusions

The scleral tissue in keratoconus and pellucid marginal corneal degeneration characterized by pathological changes with are morphological basis of its mechanical facilities disturbances. Revealed disturbances of the sclera collagenic structures leading to changes of its biomechanics properties can be one of the factors of the genetically caused progressing corneal ectasia.