gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Towards optimizing the detection of treatment-requiring acute retinopathy of prematurity (ROP)

Meeting Abstract

Suche in Medline nach

  • corresponding author B. Lorenz - Dept. of Paediatric Ophthalmology, Strabismology and Ophthalmic Genetics, Klinikum, University of Regensburg, Regensburg Externer Link

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.06.06

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter:

Veröffentlicht: 22. September 2004

© 2004 Lorenz.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen ( Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.



Prompt laser photocoagulation of treatment-requiring acute ROP is key to prevent severe visual handicap in high risk prematures. Timely detection and correct interpretation of acute ROP is hampered by enrolling ophthalmologists with limited experience in the screening process [1]. Digital wide-field imaging based telemedicine and software-based data analysis could optimize the detection of treatment-requiring acute ROP.


Several studies including our own East-Bavarian Multicenter Telemedicine Project to detect treatment-requiring ROP have been conducted to evaluate the sensitivity and specificity to detect referral-warranted ROP stages with the use of digital wide-field imaging using the RetCam120, and comparing the results with conventional screening using binocular indirect ophthalmoscopy BIO. Sensitivity and specificity of digital wide-field imaging to detect referral-warranted ROP was high when longitudinal screening was performed according to the national and international guidelines for screening [2], [3]. Within the East-Bavarian Multicenter Telemedicine Project customized software DiNO has been developed to allow standardized evaluation of digital wide-field fundus images and archiving of the paediatric data. It includes a dynamic grid positioning feature that can be superimposed to all images from the same eye and a semi-automatic quantification of the ROP stages per zone and clock hour. DiNO detected referral-warranted ROP one to 4 weeks earlier than BIO in 35%, at the same time in 61%, and one week later in 4% (125 examinations, 26 infants [4]).


Digital wide-field imaging based telemedicine and customized software for data analysis is shown to optimize detection of referral-warranted acute ROP.


Lorenz B, Bock M, Müller HM, Massie NA. Telemedicine based screening of infants at risk for retinopathy of prematurity. Stud Health Technol Inform. 1999;64:155-63
Ells AL, Holmes JM, Astle WF, et al. Telemedicine approach to screening for severe retinopathy of prematurity: a pilot study. Ophthalmology 2003;110:2113-7
Elflein HM, Lorenz B. Wide-Field-Digital-Imaging Based Telemedicine for Screening of Acute Retinopathy of Prematurity (ROP). submitted 2004
Lorenz B, Ells AL, Donaubauer M, et al. Quantitative Analysis of Digital Images in Retinopathy of Prematurity Screening Examinations - A Pilot Study. JAAPOS 2004