Artikel
The course of diabetic retinopathy after pancreas transplantation
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Autoren
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B. Breuer
- Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig
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C. Jochmann
- Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig
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H. Witzigmann
- Chirurgische Klinik und Poliklinik 2, Leipzig
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P. Meier
- Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig
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P. Wiedemann
- Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig
| Veröffentlicht: | 22. September 2004 |
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Gliederung
Text
Objective
Developed by Kelly, pancreas transplantation has been an option in treatment of diabetes mellitus type1 since 1966. The long term goal of pancreas transplantation is to restore normoglycemia in order to reverse or to stabilize diabetic microangiopathic complications. The course of diabetic retinopathy and visual acuitiy after pancreas transplantation is discussed controversially.
Methods
We evaluated 19 patients with diabetes mellitus type1 before and after a successful pancreas transplantation with a follow-up period of up to four years.
Results
After pancreas transplantation in three patients occured a drop in snellen acuity of at least three lines. Comparing pre-operative visual acuity with the best corrected post-operative acuity of the pre-operative better eye no significant statistical difference has been found. Out of 11 Patients with a follow-up period of at least two years, five patients developed neovascularizations in the first year after transplantation. Only one developed neovascularizations in a later time.
Conclusions
Even after successful pancreas transplantation without any need for exogenous insulin, patients developed neovascularization. They were found mostly in the first year after sudden normalization of metabolic control. Therefore, ophthalmological follow up in short intervals is recommended especially in the first year after transplantation.
