gms | German Medical Science

34. Internationaler Kongress der Deutschen Ophthalmochirurgen (DOC)

23.06. - 25.06.2022, Nürnberg

Earlier therapy with the fluocinolone acetonide (ILUVIEN) implant based on safety and effectiveness outcomes in the European IRISS registry study

Meeting Abstract

  • Ramin Khoramnia - Universitätsaugenklinik Heidelberg, Heidelberg
  • Tunde Peto - School of Medicine, Dentistry and Biomedical Sciences, Centre for Public Health, Belfast, UK
  • Frank H. Johannes Koch - Augenklinik, Goethe Universität Frankfurt, Frankfurt am Main
  • Simon R. Taylor - Department of Ophthalmology, University of Surrey, Guildford, UK
  • Joao Paulo Castro de Sousa - Ophthalmology Department, Leiria Hospital Center, Leiria, Portugal
  • Lauren Hill - Statistical Consultant, Bozeman, Montana, USA
  • Clare Bailey - Bristol Eye Hospital, Bristol, UK
  • Usha Chakravarthy - Centre for Public Health, Queens Universtity Belfast, Belfast, UK

34. Internationaler Kongress der Deutschen Ophthalmochirurgen. Nürnberg, 23.-25.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocWK 3.8

doi: 10.3205/22doc051, urn:nbn:de:0183-22doc0511

Veröffentlicht: 3. Juni 2022

© 2022 Khoramnia et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe



Purpose: Subgroup analysis describing outcomes in short- and long-term chronic diabetic macular edema (cDME) following fluocinolone acetonide (FAc) therapy.

Methods: European (31 UK sites, 11 in Germany and 5 in Portugal), multicentre, open-label, observational registry study of patients treated with the FAc implant for any reason. Patients treated with a FAc implant (2013–2017) were included and monitored until the last patient reached ≥3 years of follow-up. Participants with a cDME duration ≤3.6 years (n=319) were classified as ‘short-term’, and those with a duration of >3.6 years (n=322) as ‘long-term.’ Study parameters included: mean intraocular pressure (IOP), IOP events and changes in mean VA.

Results: Over 36 months, eyes with short-term cDME had a marginally lower frequency of IOP-related events compared with eyes with long-term cDME. At Month 36, eyes in the short-term cDME group experienced a sustained improvement in VA (+6.6 letters from a baseline of 52.9 letters) and this was still evident at Month 48 (+7.5 letters from baseline). In the long-term cDME group the VA change was lower at Month 36 (+1.8 letters from a baseline of 51.6 letters) and lost by Month 48 (-1.9 letters from baseline).

Conclusions: In eyes with short-term cDME, the frequency of IOP-related events were marginally lower and VA improvements were sustained, thus suggesting a positive benefit-to-risk profile in patients treated earlier with the FAc implant.