Artikel
Glistenings evaluation of the first generation of AcrySof material of 1990’s (P, B)
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Autoren
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Qiang Wang
- Universitäts-Augenklinik Heidelberg, David J. Apple International Laboratory for Ocular Pathology, Heidelberg
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Patrick R. Merz
- Universitäts-Augenklinik Heidelberg, David J. Apple International Laboratory for Ocular Pathology, Heidelberg
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Hui Fang
- Universitäts-Augenklinik Heidelberg, David J. Apple International Laboratory for Ocular Pathology, Heidelberg
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Sonja K. Schickhardt
- Universitäts-Augenklinik Heidelberg, David J. Apple International Laboratory for Ocular Pathology, Heidelberg
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Tanja M. Rabsilber
- Universitäts-Augenklinik Heidelberg, David J. Apple International Laboratory for Ocular Pathology, Heidelberg
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Gerd U. Auffarth
- Universitäts-Augenklinik Heidelberg, David J. Apple International Laboratory for Ocular Pathology, Heidelberg
| Veröffentlicht: | 27. April 2017 |
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Gliederung
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Purpose: To reproduce and evaluate glistenings of explanted 3-piece hydrophobic acrylic intraocular lenses of the initial Acrysof material implanted between 1994 to 1997 in the US.
Methods: Twenty-five 3-piece hydrophobic acrylic IOLs (Acrysof, Alcon, Fort Worth, USA) that were explanted were evaluated. Microscopic pictures of the 25 3-piece hydrophobic acrylic IOLs (original magnification X 14 and X 90) were taken under both dry and wet conditions. Then an experimental set up to visualize glistenings was applied. The IOLs were placed inside a water bath setting at a constant temperature of 37°C for 10 days. During the following 10 days, the amount of the glistenings was quantified using a professional image analysis system.
Results: The amount of glistenings was found to be variable in the IOLs during incubation at 37°C. Among all the 25 pieces of IOLs, 5 IOLs presented with 0–500 microcacuoles/mm² (MV/mm²), 11 IOLs showed 500-2000 MV/mm², 9 IOLs were found to have extreme high numbers of 2000–3500 MV/mm2.
Conclusions: Glistenings could be reproduced in the explanted IOLs immersed in the water bath at constant 37 degrees C temperature by simulating human body temperature. Despite of the same type of IOLs, the amount of reproduced glistenings in IOLs are different and roughly classified into 3 groups. The differences probably have relationship with the manufacture process, Lot-number and implant duration. Compared to similar studies at our laboratory with current hydrophobic acrylic IOLs of the same manufacturer the glistenings numbers were 10x higher in the 1990’s IOL.
