Artikel
Corneal densitometry, central cornea thickness and corneal central-to-peripheral thickness ratio in patients with Fuchs endothelial dystrophy (K)
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Autoren
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Maged Alnawaiseh
- University of Muenster Medical Center, Dept. of Ophthalmology, Muenster
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Lars Zumhagen
- University of Muenster Medical Center, Dept. of Ophthalmology, Muenster
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André Rosentreter
- University of Muenster Medical Center, Dept. of Ophthalmology, Muenster
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Nicole Eter
- University of Muenster Medical Center, Dept. of Ophthalmology, Muenster
| Veröffentlicht: | 3. Juni 2016 |
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Gliederung
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Purpose: The aim of the study was to quantify Scheimpflug corneal densitometry in patients with Fuchs endothelial dystrophy (FED).
Methods: In this study we retrospectively reviewed the charts and anterior segment data of 49 patients with FED before posterior lamellar keratoplasty and of 51 healthy controls. Patients were examined using the Scheimpflug-based Oculus Pentacam. Central corneal thickness (CCT), ring-averaged (on a circle of 2, 2.4 - 10 mm diameter) non-central corneal thickness and densitometry data in different corneal layers and in different annuli were extracted and analyzed
Results: The total corneal light backscatter at total corneal thickness and at total diameter was significantly higher in the FED-group compared with the control group (FED-group: 28.8 ± 6.7; control group: 24.3 ± 4.1; p < 0.001). Dividing the corneal surface into concentric annular zones at total corneal thickness, the differences were significant only in the two central annuli (p < 0.001). The total corneal light backscatter at total corneal thickness in the central 0-2 mm annulus correlated moderately with the central corneal thickness (Pearson correlation = 0.55, p < 0.001).
Conclusions: Corneal light backscatter in the central cornea was greater in patients with FED than in normal subjects. Corneal densitometry enables us to evaluate the optical quality of the cornea in different corneal layers and in different annuli. It is a useful, objective method that, in combination with CCT and CPTR, can help to quantify FED severity.
