Artikel
Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial
Suche in Medline nach
Autoren
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Yuxuan Cong
- Xi'an Honghui Hospital, Xi'an, China
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Binfei Zhang
- Xi'an Honghui Hospital, Xi'an, China
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Jinlai Lei
- Xi'an Honghui Hospital, Xi'an, China
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Hai Huang
- Xi'an Honghui Hospital, Xi'an, China
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Pengfei Wang
- Xi'an Honghui Hospital, Xi'an, China
| Veröffentlicht: | 22. Oktober 2019 |
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Gliederung
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Objectives: Hidden blood loss is a major concern for patients undergoing hip surgery for intertrochanteric fracture. The objective of this study was to investigate whether tranexamic acid (TXA) could reduce postoperative hidden blood loss in patients undergoing hip surgery for intertrochanteric fracture.
Methods: A total of 77 patients with intertrochanteric fracture were enrolled in this randomized controlled study. Patients received either 200 mL (1 g) of TXA (n = 37) or normal-saline (NS) (n = 40) i.v. before hip surgery using proximal femoral nail anti-rotation (PFNA). Hemoglobin and hematocrit levels were measured preoperatively and postoperatively at day 1 and 3. Visible and hidden blood loss volumes were calculated at postoperative day 3
Results and conclusion: On postoperative day 3, the transfusion rate was significantly lower in the TXA group compared to the NS group, although mean hemoglobin and hematocrit levels were not significantly different between the two groups. However, the estimated hidden blood loss volume (210.09 ± 202.14 mL vs. 359.35 ± 290.12 mL; P < 0.05) and total blood loss volume (279.35 ± 209.11 mL vs. 417.89 ± 289.56 mL; P < 0.05) were significantly less in the TXA group compared to the NS group, respectively.
TXA significantly reduced postoperative hidden blood loss in patients with intertrochanteric fracture who underwent PFNA.
