gms | German Medical Science

Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018)

23.10. - 26.10.2018, Berlin

Blood transfusion and postoperative infection in spine surgery: a systematic review

Meeting Abstract

  • presenting/speaker Christian Fisahn - Ruhr-Universität Bochum, BG-Universitätsklinikum Bergmannsheil, Chirurgische Klinik und Poliklinik, Bochum, Germany
  • Cameron Schmidt - Swedish Neuroscience Institute, Seattle, United States
  • Rod Oskouian - Swedish Neuroscience Institute, Seattle, United States
  • R. Shane Tubbs - Seattle Science Foundation, Seattle, United States
  • Thomas A. Schildhauer - BG Universitätsklinikum Bergmannsheil, Chirurgische Klinik und Poliklinik, Bochum, Germany

Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018). Berlin, 23.-26.10.2018. Düsseldorf: German Medical Science GMS Publishing House; 2018. DocPT13-1016

doi: 10.3205/18dkou615, urn:nbn:de:0183-18dkou6157

Veröffentlicht: 6. November 2018

© 2018 Fisahn et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objectives: Allogeneic blood transfusion-related immunomodulation may relatively suppress the immune system, heightening the risk of infection following spine surgery. This systematic review seeks to determine whether allogeneic blood transfusion increases the risk of postoperative infection and whether there are any factors that modify this association.

Methods: PubMed, Cochrane Central Register of Controlled Trials, and reference lists from included studies were searched from inception to April 20, 2017 to identify studies examining the risk of infection following allogeneic blood transfusion in adult patients receiving surgery for degenerative spine disease.

Results and conclusion: Eleven retrospective cohort or case-control studies, involving 8,428 transfusion patients and 43,242 non-transfusion patients , were identified as meeting the inclusion criteria. Regarding surgical site infection (SSI), the results were mixed with roughly half reporting a significant association. There was an association between allogeneic transfusion and urinary tract infection (UTI) and any infection, but not respiratory tract infection. There was no statistical modifying effect of lumbar versus thoracic surgery on the association of allogeneic transfusion and SSI, though subgroup analyses in three of four studies reported a statistical association between transfusion and postoperative infections, including SSI, UTI, and any infection within the lumbar spine.

This systematic review failed to find a consistent association between allogeneic transfusion and postoperative infection in spine surgery patients. However, these studies were all retrospective with a high or moderately high risk of bias. To properly examine this association an observational prospective study of sufficient power, estimated as 2400 patients, is required.