Artikel
Effects of NSAIDs and Hydroxyapatite Coating on Osseointegration: Biomechanical and Histological Study on Rabbits
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Veröffentlicht: | 5. Oktober 2015 |
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Gliederung
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Objectives: Osseointegration and locking between bone and prosthesis depend on inflammatory responses in arthroplastic surgery. Recently, several alternative prosthetic surfaces have been used to increase osseointegration. The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on osseointegration.
Methods: The hips of forty New Zealand white rabbits were operated upon bilaterally. Hydroxyapatite (HA) coated titanium rods were implanted into the right femur and grit blasted titanium rods were implanted into the left femur. They were randomly divided into three groups named as celecoxib, diclofenac and control. The celecoxib group received 3-mg/kg/day celecoxib (p.o.) and diclofenac group received 5-mg/kg/day diclofenac Na (i.m.), apart from regular daily food. The control group took only daily food. At the end of 8 weeks both femora of the rabbits were removed, and investigated biomechanically and histologically.
Results and Conclusion: Osseointegration properties of each surface type were compared as well as the effect of NSAIDs on ossointegration among the three medication groups. In the biomechanical investigation, HA coated implants had a better failure load than grit blasted implants (mean failure load of HA coated and porous surface implants were 443±165 N and 347±140 N, respectively). In the histological investigation, HA coated implants had significantly higher percentage of bone-implant contact than grit blasted implants (mean percentage of bone-implant contact of HA coated and grit blasted implants were 0.51±0.17 and 0.35± 0.13, respectively). There was no significant difference between grit blasted and HA coated implants in term of "total bone area ". There was no significant difference between the medication groups (control, celecoxib, and diclofenac) as a result of the biomechanical and histologic investigations.
HA coated implants may provide more tensile strength and greater bone-implant contact rate in comparison with grit blasted implants. However, there was no positive effect on peri-implant bone formation area. Although NSAIDs (celecoxib, diclofenac) were taken continuously in a long-term manner, we did not find any negative effect on the osseointegration.