Artikel
Effects of vegan versus meat-rich diet on markers of inflammation – a randomized, controlled trial
Suche in Medline nach
Autoren
Veröffentlicht: | 8. Oktober 2019 |
---|
Gliederung
Text
Background: Vegan diet has improved inflammatory activity in patients with rheumatoid arthritis (RA) in several small controlled trials. The underlying mechanism is largely unclear. Therefore, we investigated the effect of a vegan diet on markers of inflammation, which have been shown to be relevant in patients with RA, in healthy volunteers.
Methods: 53 healthy, omnivore subjects were randomized to a controlled vegan or meat-rich diet for 4 weeks following a pre-treatment phase of one week of controlled mixed diet. Primary target parameters were sialysation of immunoglobulins, percentage of regulatory t-cells and level of interleukin 10 (IL10). Usual care immune parameters used in patients with RA were secondary parameters.
Results: 26 vegans and 27 meat-rich probands were evaluated. Body weight remained stable in the two groups. No difference of primary parameters was found. In the vegan diet group total leukocytes, neutrophils and monocytes significantly decreased compared to the control group after 4 weeks (Figure 1 [Fig. 1]).
Moreover, a correlation between these parameters was found.
Conclusion: Vegan diet might affect myeloid cells but not lymphoid cells, which leads to the assumption that vegan diet contains a common triggering factor for myeloid cell lineage.