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42. Kongress der Deutschen Gesellschaft für Rheumatologie, 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie, 24. Wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie

17.-20. September 2014, Düsseldorf

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Immunoadsorption removes G-protein coupled receptor auto-antibodies in thromboangiitis obliterans (Buerger`s disease)

Meeting Abstract

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  • Peter Klein-Weigel - Helios Klinikum Buch, Klinik für Angiologie, Berlin
  • Saban Elitok - HELIOS Klinikum Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin
  • Petra Hempel - E.R.D.E.-AAK Diagnostik GmbH, Biomedizinischer Forschungscampus, Berlin
  • Anne Bohlen - HELIOS klinikum Berlin-Buch, Klinik für Angiologie, Berlin
  • Joana M. Boehnlein - HELIOS Klinikum Berlin-Buch, Klinik für Angiologie, Berlin
  • Marion Bimmler - E.R.D.E.-AAK-Diagnostik GmbH, Biomedizinischer Forschungscampus, Berlin

Deutsche Gesellschaft für Rheumatologie. Deutsche Gesellschaft für Orthopädische Rheumatologie. Gesellschaft für Kinder- und Jugendrheumatologie. 42. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 24. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR). Düsseldorf, 17.-20.09.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocVK.11

doi: 10.3205/14dgrh156, urn:nbn:de:0183-14dgrh1563

Veröffentlicht: 12. September 2014

© 2014 Klein-Weigel et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

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Background: Immunhistopathological and serological data favors an immunopathogenesis of thromboangiitis onliterans (TAO; Buerger`s disease). Immunoadsorption (IA) proved to be therapeutically effective. We focused on agonistic autoantibodies (agAAB) directed against G-protein coupled receptors (GPCR) and proved the hypothesis, that IA is able to eliminate these agAAB effectively.

Methods: Between December 2012 and December 2013 11 patients presumably suffering from TAO were treated by IA in a five day course. Two patients were excluded from analysis, because diagnosis of TAO was corrected. Blood samples were obtained before and after each IA. AgAAB-analysis was performed using specific ELISA techniques.

Results: AgAAB were detected in 7 out of 9 patients (78%).Multiple agAAB were present in 6 patients (67%). A clustering of agAAB directed against α-1-receptor loop 1 as well as against ETA-receptor loop 1 was identified, representing 66% resp. 56% of the TAO-patients. Five out of nine TAO-patients were positive for these both antibodies (56%). AgAA directed against AT-1 and PAR were seen in 3 resp. 2 patients. AgAAB directed against ETA-receptor loop1 never appeared without agAAB directed against α-1-receptor loop1. Immediately after a five day-course of IA agAAB were eliminated in all but two patients.

Conclusions: AgAAB directed against GPCR were identified in TAO patients with a clustering of agAAB directed against α-1-receptor loop1 and ETA-receptor loop1. AgAA were eliminated by IA in the majority of cases. We suggest that agAA directed against GPCR may play a role in the pathogenesis of TAO and that their elimination might be responsible for the positive effects seen in patients treated with IA.