Artikel
Early results on regenerative effects of erythropoietin in patients with burn and scald injures: “EPO in Burns”
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Veröffentlicht: | 28. September 2015 |
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Introduction: Large 3° and deep 2° thermal injuries are life threatening and wound surfaces need quick coverage. Initially, it was assumed that EPO was only a hormone affecting erythropoiesis, it has now been demonstrated in pre-clinical studies, that EPO plays a key role in its reaction to acute and chronic tissue damage. To address the clinical need for regenerative tools after thermal injury we stared to examine the effects of systemic EPO application in severely burned patients.
Methods: This trial was conducted as a randomized, controlled, double-blinded multicenter trial in German burn care centres, 84 patients were included. Primary efficiency endpoint was the complete re-epithelialisation of a defined split skin graft donor area. Secondary efficiency endpoints were: Time until complete wound healing of type 2a SDW and skin graft, cellular and molecular regenerative effects in SGDS and type 2a SDW, Endothelial Progenitor Cell (EPC) recruitment, [EPO] receptor upregulation, protein expression, organ dysfunction parameters (SOFA score), safety data, gender differences, quality of life, etc.
Results: 15 of the study patients developed 33 SAE`s, 8 SURs and 214 AE. 4 patients died due to septic complications. We could not detect a statistical significant difference between the two groups within regard of the primary endpoint. More detailed analysis revealed a tendency for a faster onset of complete reepithelialisation compared to the control group and differences between the two groups within the SOFA score.
Conclusion: The differences within the SOFA score might reflect the tissue and organ protective effects of EPO. The faster onset of complete reepithelialisation is previously described in animal models. However, these findings and hypothesis need further investigation.
Funded by the BMBF: 01 KG 0703.