Artikel
Prognostic value of the prediction scale for depression after stroke: the binational study ValiDePreS
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Veröffentlicht: | 30. April 2018 |
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Background and Purpose: Post-Stroke Depression (PSD) is a common complication. Early treatment might improve recovery. In the Netherlands, the Post-stroke Depression Prediction Scale (DePreS) was developed to predict the risk for PSD during the first week following a stroke. The DePreS has been translated to German, taking the ISPOR criteria into account (DePreS-G). The aim of this study is to determine the prognostic value of the DePreS and the DePreS-G.
Methods: An index test was applied to stroke patients within the first week following a stroke in three stroke units in the Netherlands and Germany (DePreS/DePreS-G). Patients’ inclusion criteria were no severe cognitive and psychiatric disorders at stroke onset and the ability to communicate adequately. After six weeks, a structured diagnostic interview (Composite International Diagnostic Interview) was conducted to detect a PSD (reference test). The researchers were blinded towards the results of the index test. The main outcomes were the negative predictive value, specificity and accuracy of the prediction scale.
Results: A total of 93 stroke patients were included. The estimated sample size was thus fulfilled. The prevalence of PSD was 18.3%. At a cutoff score of ≥3 an appropriate negative predictive value (0.87) with a high specificity (0.95) and accuracy (0.82) was determined.
Conclusions: The DePreS and DePreS-G are suitable for identifying a large number of stroke patients who are not at risk of PSD. Using routine data, the instrument enables clinicians to estimate the risk of PSD in the first week following a stroke.
Note: This study has been registered prospectively under DRKS00011546.