gms | German Medical Science

Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS)

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie

22.09.-24.09.2016, Hamburg

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Human cytomegalovirus tegument protein pp65 is detected in all intra- and extra-axial brain tumours independent of the tumour type or grade

Meeting Abstract

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  • presenting/speaker Sylwia Libard - Uppsala University Hospital, Department of Pathology, Uppsala, Sweden; Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden
  • S.N. Popova - Uppsala University Hospital, Department of Pathology, Uppsala, Sweden; Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden
  • R.M. Amini - Uppsala University Hospital, Department of Pathology, Uppsala, Sweden; Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden
  • V. Kärjä - Kuopio University Hospital, Department of Clinical Pathology, Kuopio, Finland
  • T. Pietiläinen - Kuopio University Hospital, Department of Clinical Pathology, Kuopio, Finland
  • K.M. Hämäläinen - Kuopio University Hospital, Department of Clinical Pathology, Kuopio, Finland
  • C. Sundström - Uppsala University Hospital, Department of Pathology, Uppsala, Sweden; Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden
  • G. Hesselager - Uppsala University Hospital, Department of Neurosurgery, Uppsala, Sweden
  • M. Bergqvist - Gävle Hospital, Department of Oncology, Centre for Research & Development, Gävle, Sweden; Umeå University, Department of radiation sciences, Umeå, Sweden
  • S. Ekman - Uppsala University, Department of Radiology, Uppsala, Sweden
  • M. Zetterling - Uppsala University Hospital, Department of Neurosurgery, Uppsala, Sweden
  • A. Smits - Uppsala University, Department of Neuroscience Neurology, Uppsala, Sweden
  • P. Nilsson - Uppsala University Hospital, Department of Neurosurgery, Uppsala, Sweden
  • S. Pfeifer - Uppsala University Hospital, Department of Women’s and Children’s Health, Uppsala, Sweden
  • T. Diaz de Ståhl - Uppsala University Hospital, Department of Pathology, Uppsala, Sweden; Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden
  • G. Enblad - Uppsala University, Department of Radiology, Uppsala, Sweden
  • F. Ponten - Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden
  • I. Alafuzoff - Uppsala University Hospital, Department of Pathology, Uppsala, Sweden; Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie. Scandinavian Neuropathological Society. Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS). Hamburg, 22.-24.09.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. Doc16dgnnP55

doi: 10.3205/16dgnn52, urn:nbn:de:0183-16dgnn525

Veröffentlicht: 14. September 2016

© 2016 Libard et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Introduction: Human cytomegalovirus (HCMV) infection has been suggested being associated with brain tumors such as glioblastoma (GBM).

Objectives: To examine expression of HCMV proteins in various brain tumors and to assess the relationship of eventual HCMV expression with the type or grade of the tumor.

Material and methods: Assessment of the performance of commercial HCMV antibodies (Abs) on brain tissue with verified HCMV infection, control brain tissue and with representative brain tumors samples to be found in a tissue microarray (TMA) block. The best performing Ab was used on the cohort of 417 cases to be found as core samples in TMA blocks.

Results: Immunoreactivity for HCMV protein was seen in 90% of tumor samples independent of type or grade of the tumor. HCMV inclusions as sign of an active infection were never seen in any of the investigated tumors.

Conclusions: Our results argue against an active HCMV infection in brain tumors but suggest that expression of HCMV proteins in brain tumors is common. The significance of the expression of HCMV tegument protein in tumors is unclear and should be further investigated.