Artikel
Microglial (dys)function in Alzheimer’s disease-like mice harboring defined Aβ species
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Autoren
Veröffentlicht: | 25. August 2015 |
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Gliederung
Text
A major pathophysiological hallmark of Alzheimer’s disease (AD) is the generation and deposition of cerebral β amyloid (Aß). Recently, we showed that microglia cells obtain an impaired function in an Aβ-dependent manner, as shown by a decrease in microglial phagocytic activity and directed process motility in Aβ depositing APPPS1 and APP23 mice [1]. Since various species and aggregation states of Aβ co-exist, most likely with varying pathogenic impact, we extended our analyses of microglial (dys)function in AD-like mouse models by investigating “oligomeric” AD-like mice carrying the Dutch mutation in the APP gene [2]. Given that these mice exhibit oligomeric Aß species and show no Aβ plaque deposition while having changes in cognition, our data will provide a better understanding of – potentially pathogenically relevant – microglial actions in AD.
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