gms | German Medical Science

60. Jahrestagung der Deutschen Gesellschaft für Neuropathologie und Neuroanatomie (DGNN)

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie

26. - 28.08.2015, Berlin

Artikel

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Microglia regulate adult-born neuroblast development and survival

Meeting Abstract

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  • presenting/speaker Caroline Baufeld - Charite, Department of Neuropathology, Berlin, Germany
  • corresponding author Kelly Miller - Charite, Department of Neuropathology, Berlin, Germany
  • Karen Carney - Charite, Department of Neuropathology, Berlin, Netherlands
  • Claudia Hempt - Charite, Department of Neuropathology, Berlin, Germany
  • Magdalena Jochner - Charite, Department of Neuropathology, Berlin, Germany
  • Stefan Prokop - Charite, Department of Neuropathology, Berlin, Germany
  • Frank Heppner - Charite, Department of Neuropathology, Berlin, Germany

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie. 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN). Berlin, 26.-28.08.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. Doc15dgnnNI5

doi: 10.3205/15dgnn21, urn:nbn:de:0183-15dgnn214

Veröffentlicht: 25. August 2015

© 2015 Baufeld et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Adult neurogenesis plays a critical role in cognition and regeneration within the central nervous system (CNS). Instigated by ex vivo studies suggesting that microglia may impact neurogenesis, we analyzed microglia distribution in the neurogenic niche and observed numerous contacts between microglia and dendrites of immature neurons. Conditional ablation of microglia from the adult mouse brain caused a selective loss of immature neurons in the dentate gyrus and subventricular zone, whilst sparing neural stem or progenitor cells. Reduced survival of immature neurons in microglia-depleted mice was accompanied by cognitive deficits, which like neurogenesis, were restored by replenishment of the microglia pool. Together with the identification of a genetic signature demonstrating distinct microglia-derived support within the hippocampus, these data reveal a population of microglia that provide cues fundamental in the development and survival of adult-born neurons, and therein further our knowledge about the increasingly diverse physiological role of microglia in the CNS.