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57. Jahrestagung der Deutschen Gesellschaft für Neuropathologie und Neuroanatomie (DGNN)

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie

12. - 15.09.2012, Erlangen

Banner: 57. Jahrestagung der Deutschen Gesellschaft für Neuropathologie und Neuroanatomie

Central myelin-peripheral myelin transitional zone of the Nervus Intermedius. Features and importance for microsurgery in the cerebellopontine angle.

Meeting Abstract

  • presenting/speaker Alex Alfieri - Martin Luther University Halle-Wittenberg, Neurosurgery, Halle (Saale), Germany
  • Julius Fleischhammer - Martin Luther University Halle-Wittenberg, Neurosurgery, Halle (Saale), Germany
  • Elmar Peschke - Martin Luther University Halle-Wittenberg, Neurosurgery, Halle (Saale), Germany
  • Christian Strauss - Martin Luther University Halle-Wittenberg, Neurosurgery, Halle (Saale), Germany

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie. 57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN). Erlangen, 12.-15.09.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12dgnnPP5.6

doi: 10.3205/12dgnn106, urn:nbn:de:0183-12dgnn1066

Veröffentlicht: 11. September 2012

© 2012 Alfieri et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Question: The aim of this study was to confirm the presence and to evaluate the histological and ultrastructural features of the central myelin-peripheral myelin transitional zone - also referred to as Obersteiner-Redlich zone (ORZ) or glial/schwann junction- of the nervus intermedius (NI).

Methods: Ten NI specimens from five fresh cadavers were microscopically analyzed for structural differences between their CNS and PNS segments. The ORZ was analyzed under a light microscope and the exact location of the ORZ was confirmed by immunohistochemical staining using an Olig2 antibody.

Results: The diameter of the NI showed a mean of 0.62 mm (range: 0.5–0.8 mm, SEM: 0.033). The cisternal segment of the NI from the brainstem to the porus acusticus internus had a mean length of 13.97 mm (range: 9–18.8 mm, SEM: 1.13). The mean extent of central myelin was 0.5 mm (range: 0.189–0.797 mm, SEM: 0.067 mm) from the brainstem on the medial side and 0.33 mm (range: 0.102–0.546 mm, SEM: 0.06 mm) on the lateral side. Moreover, the length of the ORZ had a mean of 0.279 mm (range: 0.024–0.5 mm, SEM: 0.06 mm) on the medial side and 0.134 mm (range: 0.059–0.233 mm, SEM: 0.018 mm) on the lateral side. The ORZ of the NI appears closer to the brainstem compared with the other cranial nerves.

Conclusions: Our results indicate that the ORZ of the NI is closer to the brainstem in respect to the other cranial nerves. The NI ORZ may play a role in the pathogenesis of intermediate neuralgia or spasms as a vulnerable area concerning vascular compression. The exact location of the ORZ may play a role in diagnostic preoperative imaging and in the planning of surgical procedures for NIN.