gms | German Medical Science

73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

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Effect of hearing loss in adult rats – behavioural testing and electrophysiological recordings in the prefrontal cortex

Hörverlust bei erwachsenen Ratten: Einfluss auf Verhalten und neuronale Aktivität im präfrontalen Kortex

Meeting Abstract

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  • Marie Johne - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Simeon Helgers - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Mesbah Alam - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Peter Hubka - Medizinische Hochschule Hannover, AudioNeuroTechnology, Hannover, Deutschland
  • Joachim K. Krauss - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Verena Scheper - Medizinische Hochschule Hannover, Otolaryngologie, Hannover, Deutschland
  • Andrej Kral - Medizinische Hochschule Hannover, AudioNeuroTechnology, Hannover, Deutschland
  • presenting/speaker Kerstin Schwabe - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocP092

doi: 10.3205/22dgnc402, urn:nbn:de:0183-22dgnc4022

Veröffentlicht: 25. Mai 2022

© 2022 Johne et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: In adults, hearing loss is regarded as an independent risk factor for the development of dementia. Deficits cannot be explained primarily by dysfunctional neuronal networks within the central auditory system. We here tested the impact of hearing loss in adult rats on motor, social and cognitive function. Furthermore, potential changes in the neuronal activity in the medial prefrontal cortex (mPFC) was evaluated.

Methods: In adult male Sprague Dawley rats hearing loss was induced under general anaesthesia with intracochlear injection of neomycine (n=9). Sham-operated (n=4) and naïve rats (n=8) served as controls. Postsurgical auditory brainstem response (ABR) -measurements verified hearing loss after intracochlear neomycine-injection, respectively intact hearing in sham-operated and naïve controls. In intervals of eight weeks and up to nine months after surgery rats were tested for locomotor activity (open field) and coordination (Rotarod), for social interaction and preference, and for learning and memory (4-arms baited 8-arms radial maze test). In a final setting, electrophysiological recordings were performed in the mPFC.

Results: Locomotor activity did not differ between deaf and control rats, whereas motor coordination on the Rotarod was disturbed in deaf rats (n<0.05). Learning the radial maze test was initially disturbed in deaf rats (p<0.05), whereas longitudinal testing every eight weeks did not show long-term memory deficits. Social interaction was also not affected by hearing loss. Final electrophysiological recordings in anaesthetized rats revealed reduced firing rates and enhanced irregular firing, as well as reduced oscillatory theta band activity (4-8 Hz) in the mPFC of deaf rats as compared to normal hearing controls (n<0.05).

Conclusion: Behavioral deficits together with altered neuronal activity in the mPFC after heraring loss indicate effects on neuronal networks outside the central auditory system with potential consequences on cognitive function.