Artikel
Red blood cell distribution width at admission is a predictor for poor outcome in aneurysmal subarachnoid haemorrhage
Erythrozytenverteilungsbreite bei Aufnahme ist ein Prädiktor für schlechtes Outcome nach aneurysmatischer Subarachnoidalblutung
Suche in Medline nach
Autoren
Veröffentlicht: | 25. Mai 2022 |
---|
Gliederung
Text
Objective: Elevated red blood cell distribution width (RDW) is a known predictor of inflammation and poor outcome in cardiovascular disease. However, data on patients with aneurysmal subarachnoid hemorrhage (SAH) is scarce. We therefore performed a single-center study.
Methods: 330 patients with SAH treated between 01/2014 and 01/2021 were analyzed. Patients were divided into good grade (WFNS grades I-II) versus poor grade (WFNS grades III-V) on admission. RDW was assessed at admission and daily until day 5. Outcome according to the modified Rankin scale (mRS) score was assessed at 6 months after ictus. Outcome was dichotomized into favorable (mRS 0-2) and unfavorable (mRS 3-6). Univariate and multivariate analyses were performed.
Results: 165 (50%) patients had poor outcome. High RDW was associated with poor outcome (12.9 ± 1 vs. 13.4 ± 1; p=0.01). Optimal RDW cut-off value (≤13.2/>13.2) in the prediction of outcome was determined by ROC curve analysis (AUC: 0.58; 95% CI 0.51-0.64).
In the multivariate analysis poor grade SAH (p=0.0001, OR 17, 95% CI 9 – 31) and high RDW (p=0.033, OR 2, 95% CI 1.1 – 3.8) were predictor for unfavorable outcome. Treatment modality was no predictor of outcome.
Conclusion: RDW at admission is a predictive marker for poor outcome at 6 months after SAH.