gms | German Medical Science

73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

Spreading depolarisations can be detected by photoacoustic ultrasonic imaging in the deep gyrencephalic swine brain

Spreading Depolarizations können durch photoakustische Ultraschallbildgebung im tiefen gyrencephalen Schweinehirn nachgewiesen werden

Meeting Abstract

  • presenting/speaker Renán Sánchez Porras - Evangelisches Krankenhaus Oldenburg, Universitätsklinik für Neurochirurgie, Oldenburg, Deutschland; Universitätsklinikum Heidelberg, Neurochirurgische Klinik, Heidelberg, Deutschland
  • Niklas Holzwarth - German Cancer Research Center (DKFZ), Division of Computer Assisted Medical Interventions, Heidelberg, Deutschland
  • Thomas Kirchner - German Cancer Research Center (DKFZ), Division of Computer Assisted Medical Interventions, Heidelberg, Deutschland
  • Roland Zerelles - Universitätsklinikum Heidelberg, Neurochirurgische Klinik, Heidelberg, Deutschland
  • Modar Kentar - Universitätsklinikum Heidelberg, Neurochirurgische Klinik, Heidelberg, Deutschland
  • Johannes Woitzik - Evangelisches Krankenhaus Oldenburg, Universitätsklinik für Neurochirurgie, Oldenburg, Deutschland
  • Lena Maier-Hein - German Cancer Research Center (DKFZ), Division of Computer Assisted Medical Interventions, Heidelberg, Deutschland
  • Edgar Santos - Evangelisches Krankenhaus Oldenburg, Universitätsklinik für Neurochirurgie, Oldenburg, Deutschland; Universitätsklinikum Heidelberg, Neurochirurgische Klinik, Heidelberg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocP006

doi: 10.3205/22dgnc322, urn:nbn:de:0183-22dgnc3225

Veröffentlicht: 25. Mai 2022

© 2022 Sánchez Porras et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: Spreading depolarizations (SDs) are associated with poor neurological outcomes in cerebrovascular diseases and brain trauma. Until now, the standard method to measure SDs in patients is by using electrocorticography (ECoG). There are other techniques such as laser doppler, laser speckle and intrinsic optical imaging. However, they all provide few information on SD beyond the surface. The aim of this study was to investigate if SDs can be detected by using photoacoustic ultrasonic (PAUS) imaging in the gyrencephalic swine brain and if SDs can be detected on deep cortical tissue.

Methods: A German landrace swine were used for this study. An extensive craniotomy was performed. ECoG recording strip was placed on both hemispheres. SDs were induced with a drop of KCl. After a 10min baseline, a stimulation was performed, with 30min recording after application. Stimulations were performed every 40min. A total of 5 stimulations per hemisphere were performed. Animals were monitored with PAUS for 3.5h.

Results: By offline estimation of the sO2, in each pixel of the reconstructed multispectral images, SDs were visualized as sO2changes propagating from the stimulation point though different ROIs. Estimated sO2 changes presented a good correlation with SD detected in ECoG. In PAUS a total of 18 SDs were detected during the monitoring time Figure 1 [Fig. 1]. SDs were detected up to 4mm depth. No apparent anatomical dependency was found in relationship to depth. The most predominant responses (21 ROI measurements) were a biphasic change of initial decrease plus increase of sO2 (14%); and a triphasic change of of initial decrease plus increase and decrease of sO2 (14%).

Conclusion: We conclude that PAUS can image SDs with a high resolution and high imaging depth in the gyrencephalic swine brain.