Artikel
Resilience in lower grade glioma patients
Resilienz bei Patienten mit niedergradigen Gliomen
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Veröffentlicht: | 25. Mai 2022 |
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Objective: Current data shows that resilience is an important factor in cancer patients’ well-being. It may positively influence patients’ psycho-oncological distress. Resilience is often referred to as the ability to withstand external or internal stress and can be therapeutically empowered. In the current study we aim to explore resilience of patients with lower grade glioma (LGG) and their potential influencing factors.
Methods: We performed a cross-sectional assessment of adult patients with astrocytoma or oligodendroglioma of WHO grade II & III prospectively enrolled in the LoG-Glio registry. By phone interview we assessed resilience scale (RS-13), distress thermometer (DT), MOCA (Montreal cognitive assessment) phone, internalized stigma of mental illness (ISMI), Eastern oncology group performance status (ECOG), pain scale. Typical clinical parameters as adjuvant treatment, occupational and relationship status were assessed. We performed an explorative assessment. Correlations were assessed by Spearman’s ρ.
Results: We included 74 patients. Median age was 41 years (Min 21, max 67). Median time since diagnosis was 4 years (min 1, max 13). 32 patients (43%) had a radiation therapy (RT) with consecutive chemotherapy (CT), one patient RT only and 9 patients had CT only. 28 patients (38%) showed a low, 16 (22%) a moderate and 30 (41%) a high resilience. Overall 29 patients (40%) had a pathological DT. In patients with low resilience pathological DT rate was 50%, in moderate resilience 44% and in high resilience 27%. In patients with low resilience, 50% had subnormal MOCA scores, while in moderate and high resilience it was found in 13% and 27%, only. We found significant correlations of resilience with distress (p<0.01, -.43), MOCA (p=0.039, .24), ECOG (p<0.01, -.49), stigmatization (p=0.012, -2.9), pain (p<0.01, -.47), care level (p=0.001, -.38) and occupation (p=0.01, .31). No correlations were found for education, sex, age and time since diagnosis. Even though, distress and resilience correlate with each other, distress did not correlate with occupation or care level, while relationship status only correlated with distress (p=0.01, .29).
Conclusion: In LGG psycho-oncological distress is a relevant and often underestimated burden. It significantly correlates with patients' resilience. Many of the influencing factors of resilience can be leveraged. Especially, pain, low functional status, stigmatization and occupation should be identified and targeted in the clinical routine.