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73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

Relationship between tumour size, edema and a DNA methylation-based grading system for meningiomas

Die Beziehung von Tumorgröße, Hirnödem und einem DNA methylierungsbasierten Klassifikationssystem für Meningeome

Meeting Abstract

Suche in Medline nach

  • presenting/speaker Marco Stein - Universitätsklinikum Gießen, Institut für Neuropathologie, Gießen, Deutschland
  • Silvio Ginsberg - Universitätsklinikum Gießen, Institut für Neuropathologie, Gießen, Deutschland
  • Till Acker - Universitätsklinikum Gießen, Institut für Neuropathologie, Gießen, Deutschland
  • Eberhard Uhl - Universitätsklinikum Gießen, Klinik für Neurochirurgie, Gießen, Deutschland
  • Hildegard Dohmen - Universitätsklinikum Gießen, Institut für Neuropathologie, Gießen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocV042

doi: 10.3205/22dgnc050, urn:nbn:de:0183-22dgnc0508

Veröffentlicht: 25. Mai 2022

© 2022 Stein et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: Recent studies have found that methylation classes (MC) of meningiomas are highly predictive for tumor recurrence and are more precise for risk stratification than the current WHO classification. However, no association has been shown between meningioma tumor size and MC. The objective of this study was to investigate the relationship between tumor size, edema, and MC.

Methods: DNA-methylation patterns meningiomas were grouped into MC benign 1 through 3 (ben-1, ben-2, ben-3), MC intermediate (int-A and int-B), and MC malignant (MAL) like in previous publications described. A 3D-volumetry for tumor and edema size was calculated for each patient. Tumor progression was evaluated in serial MRI scans. Univariate and multivariate logistic regression models were used to investigate the relationship between MC, edema, and tumor size.

Results: In 144 patients the incidence of MC ben-1, ben-2, ben-3, int-A, int-B, and MAL was 34 (23.6%), 44 (30.6%), 7 (4.95%), 48 (33.3%), 6 (4.2%), and 5 (3.5%), respectively. Higher rates of edema were found in the two MC intermediate compared to the three MC benign [Mean 17.2cm³; Range 0-112.8cm³ vs 8.5cm³; Range 0-92.8cm³ (P=0.047)]. In this line, tumor volumes were higher in MC intermediate compared to MC benign [Mean 38.3cm³; Range 1.1-157.0cm³ vs 19.9cm³; Range 0-184.1cm³ (P=0.002)]. Early tumor progression was observed in 13 patients [Median 23 months (P25-75: 17 months to 52 months)]. Independent factors for early tumor progression were higher MC class (OR: 5.51 / 95% CI: 1.62-18.71; P=0.06), higher tumor volume (OR: 1.02 / 95% CI: 1.01-1.04; P=0.037), and higher Simpson grade (OR: 1.96 / 95% CI: 1.01-3.82; P=0.047).

Conclusion: Larger tumor and edema size are associated with a greater likelihood of a MC intermediate. Independent factor for early progression are higher MC class, higher tumor volume, and higher Simpson grade.