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72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

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Health related quality of life in patients with medically treated cerebral cavernous malformation related epilepsy

Gesundheitsbezogene Lebensqualität bei Patienten mit medizinisch behandelter zerebraler kavernöser Fehlbildung bei Epilepsie

Meeting Abstract

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  • presenting/speaker Alejandro Nicolas Santos - University Hospital Essen, Essen, Essen, Deutschland
  • Marvin Darkwah Oppong - University Hospital Essen, Essen, Essen, Deutschland
  • Laurèl Rauschenbach - University Hospital Essen, Essen, Deutschland
  • Annika Herten - University Hospital Essen, Essen, Deutschland
  • Bixia Chen - University Hospital Essen, Essen, Essen, Deutschland
  • Dino-Vitali Saban - University Hospital Essen, Essen, Deutschland
  • Thiemo Florin Dinger - University Hospital Essen, Essen, Essen, Deutschland
  • Ramazan Jabbarli - University Hospital Essen, Essen, Essen, Deutschland
  • Karsten Henning Wrede - University Hospital Essen, Essen, Essen, Deutschland
  • Ulrich Sure - University Hospital Essen, Essen, Deutschland
  • Philipp Dammann - University Hospital Essen, Essen, Essen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocP188

doi: 10.3205/21dgnc469, urn:nbn:de:0183-21dgnc4699

Veröffentlicht: 4. Juni 2021

© 2021 Santos et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

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Objective: To estimate the health-related quality of life (HRQOL) in patients with untreated cerebral cavernous malformation related epilepsy (CRE).

Methods: We performed a prospective cross-sectional study on patients with CRE admitted to our hospital between 2018 and 2020 using standardized interviews such as the hospital anxiety/depression scale (HADS-D-A/D), quality of life questionnaire (SF-36) and visual analogue scale (VAS) assessing subjective CRE disease burden. CRE patients surgically treated prior to our assessment, with incomplete clinical data and with insufficient knowledge of German language were excluded from the study. Health-related quality of life (HRQOL) data were analyzed and compared to an age- and sex-matched German normal population. Uni- and multivariate analyses were carried out to identify variables that show an impact on HRQOL outcome.

Results: We included 37 CRE patients with a mean age of 46.7 ± 13.6 years (SD). 18 (48.6%) patients presented with symptomatic hemorrhage (SH) and 20 (54.1%) had multiple CCM. 15 patients (40,5%) suffered from comorbidities. 25 patients (67.6%) had only 1 seizure. 29 patients (78.4%) received anticonvulsive therapy at time of HRQOL assessment. The mean time between last CCM-related seizure and HRQOL survey was 41.7 ± 84.6 months (SD). CRE patients showed significantly lower scores in some of the SF-36 subdomains such as physical (RP) (p = 0,007), social (SF) (p = 0,001) and emotional functioning (RE) (p < 0,001), as well as in the mental health component score (MCS) (p = 0.001). Univariate and multivariate analysis identified multiple seizures, timeframe of more than 3 months between first and last seizure and comorbidities as predictors of HRQOL impairment. A significant correlation between VAS and MCS confirmed that the decreased HRQOL values are largely based on CRE manifestation.

Conclusion: We present an observational study on HRQOL in patients with untreated CRE. Patients with CRE revealed in some domains a decreased HRQOL compared to the normal population, even when not suffering from functional impairment. Our data reflects the disease burden of patients with CRE.