Artikel
MIB-1 index in meningioma correlates to clinical improvement after surgical resection
Der MIB-1-Index von Meningeomen korreliert mit einer klinischen Verbesserung nach Resektion
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Veröffentlicht: | 4. Juni 2021 |
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Gliederung
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Objective: High MIB-1-scores correlates with new cranial nerve deficits after resection of skull base meningioma. However, the role of MIB-1 as an indicator of systemic inflammation on functional impairment at presentation and at follow-up is unclear.
Methods: 445 patients with meningioma were analyzed. Indicators of systemic inflammation, i.e. serum C-reactive protein (CRP), and white blood cell (WBC) count were assessed. Karnofsky performance status (KPS) score was assessed prior surgery, at 3 months, and at 12 months after treatment. Patients were divided into two groups, low (≤4%), and high (>4%) MIB-1-score. Univariate and multivariate analyses were performed.
Results: KPS score did not differ pre-operatively. CRP levels did not differ between the groups. WBC counts were significantly higher in the high Mib-1-score group (10.3 versus 8.9; p= 0.01). The rate of presurgical administration of corticosteroids did not differ between the groups.
In the multivariate analysis, patients with high Mib-1-score (>4%) were more likely to have a clinical improvement after surgical treatment, compared to patients with low MIB-1 score (p=0.01, OR 2.2, 95% CI 1.2 - 4). KPS score after 12 months did not differ between the groups.
Conclusion: While the underlying mechanism is not clear, patients with high MIB-1 score seem to have a higher rate of clinical improvement after surgery at 3 months, compared to patients with low MIB-1 score.