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72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

MIB-1 index in meningioma correlates to clinical improvement after surgical resection

Der MIB-1-Index von Meningeomen korreliert mit einer klinischen Verbesserung nach Resektion

Meeting Abstract

  • presenting/speaker Tim Lampmann - Rheinische Friedrich-Wilhelms-University of Bonn, Klinik und Poliklinik für Neurochirurgie, Bonn, Deutschland
  • Matthias Schneider - Rheinische Friedrich-Wilhelms-University of Bonn, Klinik und Poliklinik für Neurochirurgie, Bonn, Deutschland
  • Harun Asoglu - Rheinische Friedrich-Wilhelms-University of Bonn, Klinik und Poliklinik für Neurochirurgie, Bonn, Deutschland
  • Alexis Hadjiathanasiou - Rheinische Friedrich-Wilhelms-University of Bonn, Klinik und Poliklinik für Neurochirurgie, Bonn, Deutschland
  • Ági Güresir - Rheinische Friedrich-Wilhelms-University of Bonn, Klinik und Poliklinik für Neurochirurgie, Bonn, Deutschland
  • Hartmut Vatter - Rheinische Friedrich-Wilhelms-University of Bonn, Klinik und Poliklinik für Neurochirurgie, Bonn, Deutschland
  • Patrick Schuss - Rheinische Friedrich-Wilhelms-University of Bonn, Klinik und Poliklinik für Neurochirurgie, Bonn, Deutschland
  • Erdem Güresir - Rheinische Friedrich-Wilhelms-University of Bonn, Klinik und Poliklinik für Neurochirurgie, Bonn, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocP043

doi: 10.3205/21dgnc331, urn:nbn:de:0183-21dgnc3313

Veröffentlicht: 4. Juni 2021

© 2021 Lampmann et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: High MIB-1-scores correlates with new cranial nerve deficits after resection of skull base meningioma. However, the role of MIB-1 as an indicator of systemic inflammation on functional impairment at presentation and at follow-up is unclear.

Methods: 445 patients with meningioma were analyzed. Indicators of systemic inflammation, i.e. serum C-reactive protein (CRP), and white blood cell (WBC) count were assessed. Karnofsky performance status (KPS) score was assessed prior surgery, at 3 months, and at 12 months after treatment. Patients were divided into two groups, low (≤4%), and high (>4%) MIB-1-score. Univariate and multivariate analyses were performed.

Results: KPS score did not differ pre-operatively. CRP levels did not differ between the groups. WBC counts were significantly higher in the high Mib-1-score group (10.3 versus 8.9; p= 0.01). The rate of presurgical administration of corticosteroids did not differ between the groups.

In the multivariate analysis, patients with high Mib-1-score (>4%) were more likely to have a clinical improvement after surgical treatment, compared to patients with low MIB-1 score (p=0.01, OR 2.2, 95% CI 1.2 - 4). KPS score after 12 months did not differ between the groups.

Conclusion: While the underlying mechanism is not clear, patients with high MIB-1 score seem to have a higher rate of clinical improvement after surgery at 3 months, compared to patients with low MIB-1 score.