gms | German Medical Science

72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

Predictors of health-related quality of life after WHO grade I meningioma surgery

Prädiktoren der gesundheitsbezogenen Lebensqualität nach der Resektion von Meningeomen WHO-Grad I

Meeting Abstract

  • presenting/speaker Christine Jungk - Ruprecht-Karls-University Heidelberg, Department of Neurosurgery, Heidelberg, Deutschland
  • Madlen Rädel - Ruprecht-Karls-University Heidelberg, Department of Neurosurgery, Heidelberg, Deutschland
  • Julia Mattern-Tremper - Ruprecht-Karls-University Heidelberg, Department of Neurosurgery, Heidelberg, Deutschland
  • Christel Herold-Mende - Ruprecht-Karls-University Heidelberg, Department of Neurosurgery, Heidelberg, Deutschland
  • Andreas W. Unterberg - Ruprecht-Karls-University Heidelberg, Department of Neurosurgery, Heidelberg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocV161

doi: 10.3205/21dgnc156, urn:nbn:de:0183-21dgnc1567

Veröffentlicht: 4. Juni 2021

© 2021 Jungk et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: Intracranial meningioma WHO grade I is considered a benign disease with long-term disease control after extensive surgery. However, the psychooncological burden of these patients is still poorly defined. Here, we sought to analyse health-related quality of life (QoL) after meningioma resection.

Methods: We performed a retrospective cross-sectional analysis of health-related QoL in our institutional cohort of patients with surgery as the first intervention for intracranial meningioma. Standardized self-assessment questionnaires (HADS-D, EORTC-QLQ-C30) were sent out by mail after written informed content. Results were correlated with demographic, tumour- and treatment-related factors by univariate und multivariate linear regression and were compared to normative data derived from the general German population. Time-dependent effects of QoL data were assessed by Spearman correlation.

Results: Out of 653 patients addressed, 327 patients with intracranial meningioma WHO grade I returned the questionnaires. 81% were female, median age at diagnosis was 56 years and skull base and other tumour locations were evenly distributed (53% vs. 47%). Extent of resection was Simpson grade 1-3 in 86% and 4% underwent postoperative radiotherapy. Recurrence occurred in 17% after a median follow-up of 38 months. Health related QoL was assessed at a median interval of 31 months after last intervention. 34% and 24% of patients were screened positive on the anxiety and depression subscales of HADS-D as opposed to 21% and 24% of the general population. Compared to normative data, patients reported impaired QoL based on all function and symptom scales of EORTC-QLQ-C30. Noteworthy, both HADS-D and QLQ-C30 scores improved significantly in a time-dependent manner and levelled with the general population 5 years after last intervention. For the majority of QLQ-C30 subscales, female sex, residual disease (Simpson grade 4-5) and tumour recurrence were identified as independent predictors of impaired QoL.

Conclusion: Despite the supposedly benign nature of this disease, QoL of meningioma WHO grade I patients was impaired compared to the general population but improved significantly with increasing distance from the last intervention, indicating that the need for psychooncological intervention is highest in the first years after index surgery. Independent predictive factors of impaired QoL identified in this cohort can only in part be modified by tumour treatment.