Artikel
Postoperative olfaction and gustatory impairment in patients operated on neoplasia affecting the trigeminal pathway
Postoperative Riech- und Geschmacksbeeinträchtigung in Patienten operiert an Neoplasien im Verlauf der trigeminalen Bahn
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Autoren
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Dino Podlesek
- Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Neurochirurgie, Dresden, Deutschland
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Frederike Weitkamp
- Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Interdisziplinäres Zentrum für Riechen und Schmecken, Dresden, Deutschland
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Gabriele Schackert
- Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Neurochirurgie, Dresden, Deutschland
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Thomas Hummel
- Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Interdisziplinäres Zentrum für Riechen und Schmecken, Dresden, Deutschland
| Veröffentlicht: | 4. Juni 2021 |
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Gliederung
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Objective: Trigeminal and olfactory synergisms are crucial for a competent perception of smell and taste. Therefore, our intention was to demonstrate the impairment of olfaction and taste in patients operated on acoustic neurinoma, meningioma and other neoplasia affecting the anatomical course of trigeminal nerve.
Methods: The postoperative study comprised 49 patients with acoustic neurinoma (n=24), meningioma (n=19), trigeminal neurinoma (n=5) and one mature teratoma. 29 women and 20 men were included into study. The control group was composed of 36 healthy subjects. Comprehensive assessment of olfactory and gustatory function was conducted with the “Sniffin’ Sticks” test kit and a chemosensory quasi-threshold test (taste strips). Prior to that, broad clinical examination of patients and control group was carried out.
Results: In comparison to patients with acoustic neurinomas, patients with meningiomas (posterior and middle fossa) and patients with trigeminus neurinomas have significantly lower function for smell and taste (odor threshold: p=0.017; odor discrimination: p<0.001; TDI score: p=.003). In contrast, patients with acoustic neuromas have significantly lower taste function at the affected side (taste strips at affected side: p=0.002; no significant difference for the healthy side: p=0.76). However, the 3 groups were not significantly different in terms of sensitivity towards trigeminal stimuli (CO2). The sense of smell in patients operated on tumor affecting N.V. is decreased compared to controls (odor threshold: p=0.049; odor identification: p<0.001; TDI score: p=.001).
Conclusion: Benign neoplasia can impair and hinder the integrity of trigeminal and olfactory pathways and thereby interfere their alliance that is crucial for preserving proficient olfaction and gustatory competence.
