gms | German Medical Science

72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

Dissociation of the structural and functional connectome in glioma patients

Dissoziation des strukturellen und funktionellen Konnektoms bei Gliompatienten

Meeting Abstract

  • Kerstin Jütten - Universitätsklinikum Aachen, Klinik für Neurochirurgie, Aachen, Deutschland
  • Leon Weninger - Universitätsklinikum Aachen, Imaging & Computer Vision, Aachen, Deutschland
  • Verena Mainz - Universitätsklinikum Aachen, Institut für Medizinische Psychologie und Medizinische Soziologie, Aachen, Deutschland
  • Ferdinand Binkofski - Universitätsklinikum Aachen, Kognitive Neurologie, Neurologische Klinik, Aachen, Deutschland
  • Martin Wiesmann - Universitätsklinikum Aachen, Institut für diagnostische und interventionelle Neuroradiologie, Aachen, Deutschland
  • Hans Clusmann - Universitätsklinikum Aachen, Klinik für Neurochirurgie, Aachen, Deutschland
  • presenting/speaker Chuh-Hyoun Na - Universitätsklinikum Aachen, Klinik für Neurochirurgie, Aachen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocV111

doi: 10.3205/21dgnc106, urn:nbn:de:0183-21dgnc1069

Veröffentlicht: 4. Juni 2021

© 2021 Jütten et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe



Objective: Functional integrity is believed to be tightly bound to structural integrity in the healthy brain. Diffuse infiltrative glioma however disrupts structural white matter integrity and may impact on functional connectivity, both of peritumoral and distant brain regions. Whether structural and functional connectivity (SC, FC) are interdependent in glioma patients, diverge regionally, or differ depending on tumor growth dynamics remains unclear. We analyzed potential correlations of FC and SC in glioma patients under consideration of tumor site and IDH mutation status.

Methods: 27 glioma patients (15 IDHmut, 12 IDHwt) and 27 healthy controls underwent diffusion-weighted imaging and resting-state-fMRI. Patients were enrolled preoperatively. Whole-brain (WB) and default-mode network (DMN) parcellations were based on the Brainnetome atlas, and corresponding SC and FC matrices were determined for each subject. SC measures comprised the number of fibers (NF), and the mean fractional anisotropy (FA) of fibers connecting two regions, based on free-water corrected probabilistic tractography. FC measures comprised the correlation between the mean time-series of structurally connected regions. SC as well as FC submatrices of ipsi-, contra-lesional and interhemispheric connectivity were compared across groups, and partial correlations (p<0.05, uncorrected) analyzed for corresponding SC and FC submatrices.

Results: Patient groups and healthy controls differed neither in FC nor in NF. By trend, however, mean FA values were lower in IDHwt as compared to IDHmut patients across all submatrices. Correlation analyses revealed intramodal associations within SC and FC matrices, both for patients and controls. But while in controls, FA and NF were associated across all submatrices, only few associations were found in IDHmut patients (FAcontra and FAinter with NFipsi and NFcontra), but none in the IDHwt group. Furthermore, healthy subjects showed SC-FC correlations for WB as well as within the DMN, while neither IDHmut nor IDHwt patients showed any association between SC and FC measures.

Conclusion: Microstructural integrity of the structural connectome seemed to be altered in the prognostically less favorable IDHwt patients, even in tumor distant regions. While FC may not yet be altered, the dissociation of SC and FC might be an early indicator of network desintegration in glioma patients.