Artikel
Neural architecture of the septum verum – a fibre dissection study
Neuraler Aufbau des Septum verum
Suche in Medline nach
Autoren
-
László Bárány
- Semmelweis University, Department of Anatomy, Histology and Embryology, Budapest, Hungary
-
Oliver Ganslandt
- Katharinenhospital Klinikum Stuttgart, Neurochirurgische Klinik, Stuttgart, Deutschland
-
Michael Buchfelder
- Friedrich-Alexander-Universität Erlangen-Nürnberg, Neurochirurgische Klinik, Erlangen-Nürnberg, Deutschland
-
Péter Kurucz
- Katharinenhospital Klinikum Stuttgart, Neurochirurgische Klinik, Stuttgart, Deutschland; Friedrich-Alexander-Universität Erlangen-Nürnberg, Neurochirurgische Klinik, Erlangen-Nürnberg, Deutschland
| Veröffentlicht: | 26. Juni 2020 |
|---|
Gliederung
Text
Objective: The septum verum is the ventral part of the human septum that contains well developed nuclei, such as the bed nucleus of stria terminalis (BNST) as well as the septal nuclei. The BNST is a potential target of deep brain stimulation (DBS) in patients with various psychiatric disorders, such as drug resistant obsessive-compulsive disorder or anorexia nervosa. The nuclei septales were proposed as possible targets of DBS in patients with traumatic brain injury. The comprehensive description of the three-dimensional anatomy of the septum verum, its connections and the adjacent structures is lacking in the literature.
Methods: Six cadaveric human brains (12 hemispheres) were involved in this study. Five of them were fixed in 5% formalin and freezed on -30 °C according to the well-known method of Klingler. The brains were halved and dissected from medial to lateral and from inferior to superior direction. The fiber dissection was carried out with microsurgical instruments and with the aid of an operating microscope. The macroscopic findings were controlled and verified with histology in one brain.
Results: The septum verum is located under the septum pellucidum, in the ventral part of the septum telencephalic that separates the two lateral ventricles. The following connections were successfully identified:
- 1.
- the precommissural fibers of the fornix;
- 2.
- the fasciculus inferior of the septum pellucidum;
- 3.
- the stria medullaris of thalamus;
- 4.
- the stria terminalis;
- 5.
- the ventral amygdaloseptal fibers;
- 6.
- and the stria olfactoria medialis.
The postcommissural fibers of the fornix, the mammillothalamic fascicle, the cingulum as well as the inferior and anterior peduncles of the thalamus were demonstrated in all cases.Fibers originating from the stria medullaris of thalamus and crossing through the massa intermedia as well as fibers between the postcommissural portion of the fornix and the stria medullaris of thalamus were constant findings during the dissections.
Conclusion: Understanding the three-dimensional anatomy of the septum verum may help to improve the accuracy of electrode implantation during DBS as well as interpretation the side effects that originate from incorrect electrode placement.
