Artikel
Disturbed cortical network beta resonance to transcranial magnetic stimulation elucidates motor dysfunction despite intact cortico-spinal integrity
Eine Störung der kortikalen β-Resonanz nach transkranieller Magnetstimulation als electrophysiologischer Marker einer motorischen Störung trotz erhaltener kortospinaler Integrität
Suche in Medline nach
Autoren
Veröffentlicht: | 26. Juni 2020 |
---|
Gliederung
Text
Objective: The synchronization of functionally related brain areas creates a channel for effective communication. In the motor system, these coherent oscillations occur within the beta-band frequency range. However, it is currently unknown what role the cortical beta resonance plays in the behavioral output of the motor system. By utilizing a noninvasive stimulation method, the functional significance of beta-band synchronization in large-scale interactions can be explored using the partly disrupted network state.
Methods: To investigate this, the present study characterizes the electroencephalographic (EEG) response to transcranial magnetic stimulation (TMS) applied to primary motor cortex (M1) at rest in twelve patients with tumors residing in motor eloquent areas. Electrophysiological results were compared to clinical motor performance measurements.
Results: Results indicate that lesions based in the cortical motor system areas disrupt the natural beta resonance response of M1 to a TMS pulse. Results further provided evidence that the motor system dysfunction occurs in spite of an undisturbed corticospinal tract, and instead relates to a weakened ability of the cortical motor network to synchronize.
Conclusion: These results demonstrate that a behavioral malfunction can relate to changes in the selective frequency of the brain network, as an altered cortical resonance accumulates in effect to impair the motor performance. Thus, TMS-EEG recordings could be used in neurosurgery to predict behavioral outcome after brain surgery.