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71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

21.06. - 24.06.2020

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Peri-interventional behaviour of neutrophil to lymphocyte ratio in patients with intracranial aneurysms

Periinterventionelle Bedeutung von Neutrophilen-Lymphozyten-Ratio in Patienten mit intrakraniellen Aneurysmen

Meeting Abstract

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  • presenting/speaker Anna Cho - Medizinische Universität Innsbruck, Universitätsklinik für Neurochirurgie, Wien, Austria
  • Thomas Czech - Medizinische Universität Innsbruck, Universitätsklinik für Neurochirurgie, Wien, Austria
  • Wei-Te Wang - Medizinische Universität Innsbruck, Universitätsklinik für Neurochirurgie, Wien, Austria
  • Philippe Dodier - Medizinische Universität Innsbruck, Universitätsklinik für Neurochirurgie, Wien, Austria
  • Andrea Reinprecht - Medizinische Universität Innsbruck, Universitätsklinik für Neurochirurgie, Wien, Austria
  • Gerhard Bavinzski - Medizinische Universität Innsbruck, Universitätsklinik für Neurochirurgie, Wien, Austria

Deutsche Gesellschaft für Neurochirurgie. 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. sine loco [digital], 21.-24.06.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. DocV114

doi: 10.3205/20dgnc116, urn:nbn:de:0183-20dgnc1160

Veröffentlicht: 26. Juni 2020

© 2020 Cho et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: The Neutrophil-to-Lymphocyte-Ratio (NLR) has already been investigated as an independent predictive marker for clinical outcome in vascular diseases. This study aimed to investigate the peri-interventional behavior of NLR in patients with ruptured and unruptured intracranial aneurysms (IAs).

Methods: 117 patients with IAs, who were treated in our department and had available completed data, were retrospectively identified during a ten-year period. Routine laboratory parameters, including neutrophil and lymphocytes, were measured at baseline and follow-up (FUP) visits.

Results: The baseline NLR showed significant differences between patients with ruptured and unruptured IAs [6.3 (IQR 4.2-9.0) vs. 1.8 (IQR 1.6-2.3), p<0.001]. In patients with ruptured IAs, baseline NLR significantly decreased during the FUP visits, while in unruptured IAs, the NLR remained low. In patients with ruptured IAs, higher baseline NLR values could be observed in patients with fatal outcome, in comparison to surviving patients [8.0 (IQR 5.2 -9.1) vs. 5.4 (IQR 4.0-9.0); p=0.220]. In patients with poor functional outcome, defined as modified Rankin Score (mRS) 33, NLR was significantly higher before treatment [7.2 (IQR 4.7-9.6) vs. 5.3 (IQR 3.5-8.1); p=0.047], but also at day 10 [5.4 (IQR 3.9-6.8) vs. 4.2 (IQR 3.3-5.9); p=0.025] and one month after treatment [3.5 (IQR 2.5-5.8) vs. 2.3 (IQR 1.7-2.9); p=0.001].

Conclusion: The peri-interventional NLR was significantly different between patients with ruptured and unruptured IAs. In patients with ruptured IAs, elevated baseline NLR levels was associated with poor postoperative functional outcomes and decreased postoperatively, implying the potential prognostic importance of NLR in patients with IAs.

Figure 1 [Fig. 1]