Artikel
The prognostic role of H3K27 trimethylation in meningioma
Die prognostische Wertigkeit der H3K27 Trimethylierung in Meningeomen
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Autoren
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Felix Behling
- Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland
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Christina-Katharina Fodi
- Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland
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Irina Gepfner-Tuma
- Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland; Universitätsklinikum Tübingen, Klinik für Neurologie, Tübingen, Deutschland
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Kathrin Machetanz
- Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland
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Kristina Kaltenbacher
- Universitätsklinikum Tübingen, Klinik für Neurologie, Tübingen, Deutschland
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Mirjam Renovanz
- Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland
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Marco Skardelly
- Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland
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Marcos Tatagiba
- Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland
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Ghazaleh Tabatabai
- Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland; Universitätsklinikum Tübingen, Klinik für Neurologie, Tübingen, Deutschland
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Jens Schittenhelm
- Universitätsklinikum Tübingen, Institut für Neuropathologie, Tübingen, Deutschland
| Veröffentlicht: | 26. Juni 2020 |
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Gliederung
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Objective: The prognostic role of the histone methylation H3K27 in meningioma has been described recently and is currently examined in several cancer types. The methylation can be detected immunohistochemically and is potentially integrable into daily neuropathology practice to provide prognostic information after meningioma resection. The objective of this study was to assess the prognostic value of H3K27 histone methylation in a large cohort of meningiomas to provide more evidence and support for its clinical application.
Methods: In a retrospective analysis tumor specimen of 429 patients with meningiomas who underwent surgery from April 2011 to December 2015 in our department were assessed for H3K27me3 immunohistochemically. Further clinical data (WHO classification, brain invasion, Simpson grade, age, gender, progression free survival) were derived from medical records. Univariate analysis was done with Fisher’s exact and Log-Rank test and multivariate analysis via linear regression.
Results: A total of 429 meningiomas were analyzed with a female to male ratio of 3.2, mean age at diagnosis of 59 years (range 15.84 – 89.95) and mean follow-up at 31 months (range 1.76 – 95.72). Univariate analysis showed a significant negative prognostic impact of male gender (p=0.0236), WHO grade II/III (p=0.0057), Simpson grade >2 (p<.0001) and H3K27me3 loss (p=0.0007). In the multivariate analysis only Simpson grade and H3K27me3 status remained independent prognostic factors for meningioma recurrence (p = 0.0001 and 0.0084, respectively). H3K27 trimethylation loss was more common in male patients in this cohort explaining the loss of prognostic impact of gender after inclusion of the histone methylation status in the multivariate analysis.
Conclusion: Loss of the trimethylation of H3K27 is an independent prognostic factor together with Simpson grade in our cohort and in line with prior studies. The growing evidence suggests the integration of H3K7me3 immunohistochemistry into neuropathology practice for meningiomas.
