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70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12.05. - 15.05.2019, Würzburg

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The characteristics of cerebral aneurysms in young patients with tuberous sclerosis

Merkmale zerebraler Aneurysmen von jungen Patienten mit tuberöser Sklerose

Meeting Abstract

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  • presenting/speaker Mehdi Chihi - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Oliver Gembruch - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Marvin Darkwah Oppong - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Thiemo Florin Dinger - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Daniela Pierscianek - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Ulrich Sure - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Ramazan Jabbarli - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocP117

doi: 10.3205/19dgnc453, urn:nbn:de:0183-19dgnc4537

Veröffentlicht: 8. Mai 2019

© 2019 Chihi et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: Tuberous sclerosis complex (TSC) is a rare multisystem genetic disease. Arterial wall developmental disorders in TSC such as aneurysms have been well described for extracranial vasculature. The characteristics of intracranial aneurysms (IA) in TSC have not been addressed in the literature yet. This study aimed to perform a systematic review to identify and assess the distinct characteristics of IA in patients with TSC.

Methods: We searched PubMed, Scopus and Web of Science for publications describing cases with TSC and IA reported before August 7th, 2018. Moreover, we report two cases of IA in TSC patients treated at our institution.

Results: Thirty-three TSC patients with a total of 42 IA were included in this review. Three individuals presented with subarachnoid hemorrhage. IA were large or giant in 57.1% and fusiform in 45.2% of the cases. Most of the IA originated from the ICA (61.9%, n=26). There was a higher prevalence of pediatric cases (66.7%) and male patients (63.6%, 21 of 32 individuals with known sex) in the collected series.

Conclusion: TSC patients with IA are characterized with a higher proportion of large/giant and fusiform IA in young patients, so that a rapid aneurysmal growth was suspected. Furthermore, there is a distinct location pattern of IA and an inverse sex ratio in comparison to the healthy population. Large population-based patient registers are required for a better understanding of epidemiology and pathophysiology of IA formation in TSC.