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70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12.05. - 15.05.2019, Würzburg

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Cerebral cavernous malformation (CCM) – experience of a specialised cavernoma outpatient clinic with more than 1000 cases

Zerebrale kavernöse Malformationen – Erfahrungen aus einer Spezialsprechstunde mit über 1000 Fällen

Meeting Abstract

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  • presenting/speaker Philipp Dammann - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Dino Saban - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Steffen Rauscher - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Annika Herten - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Ramazan Jabbarli - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Karsten Wrede - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland
  • Ulrich Sure - Universitätsklinikum Essen, Neurochirurgie, Essen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocV307

doi: 10.3205/19dgnc325, urn:nbn:de:0183-19dgnc3254

Veröffentlicht: 8. Mai 2019

© 2019 Dammann et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: To report on baseline characteristics, effectors and treatment rates in a large cohort of CCM presenting in a cavernoma outpatient clinic providing a specialized consultation since 2008.

Methods: We browsed our uni-center CCM database (2003–2018) to summarize baseline data and analyze for effectors and treatment rates. All clinical and radiological baseline data were assessed according to inhouse and common reporting standards. Radiological data was only assessed when imaging was stored in local PACS.

Results: So far, datasets of n=1003 qualified patients (further 400 datasets have to be checked) were completed, cleaned and analyzed. 60.1% of patients were female. Mean age was 40.7±15.9 years. 47.5% presented with a symptomatic hemorrhage (SH), 19.3% with a cavernoma related epilepsy (CRE), 37.7% were asymptomatic, 19.2% presented with multiple CCM. Supratentorial, brainstem, cerebellar and spinal location were found in 63%, 22%, 9% and 6%, respectively. A typical DVA was found in 29.4% of cases. 31% of all patients that presented underwent surgery. Admissions significantly increased since 2008, while treatment rates continue to decrease since 2010. Multivariate analysis revealed that younger age, brainstem location and absence of DVA were associated with a higher risk of presenting with SH. Larger lesion volume (CCM plus hemorrhage) was associated with absence of DVA and younger age as well.

Conclusion: This large university center cohort confirms previous epidemiological data but also provides new and controversial data (role of DVA). It also reflects the more and more cautious indications for surgical treatment during the last 10 years.