gms | German Medical Science

70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12.05. - 15.05.2019, Würzburg

Previous clinical history of any other unrelated tumour is a negative prognostic factor for tumour recurrence in completely excised meningiomas WHO grade I

Positive Tumoranamnese bei Patienten mit komplettresezierten Meningiomen WHO Grad I ist ein negativer prognostischer Faktor

Meeting Abstract

  • presenting/speaker Annamaria Biczok - Klinikum der Ludwig-Maximilians-Universität – Campus Großhadern, Neuropathologie, München, Deutschland
  • Markus Lenski - Klinikum der Ludwig-Maximilians-Universität – Campus Großhadern, Neurochirurgie, München, Deutschland
  • Rupert Egensperger - Klinikum der Ludwig-Maximilians-Universität – Campus Großhadern, Neuropathologie, München, Deutschland
  • Jörg-Christian Tonn - Klinikum der Ludwig-Maximilians-Universität – Campus Großhadern, Neurochirurgie, München, Deutschland
  • Christian Schichor - Klinikum der Ludwig-Maximilians-Universität – Campus Großhadern, Neurochirurgie, München, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocV241

doi: 10.3205/19dgnc260, urn:nbn:de:0183-19dgnc2603

Veröffentlicht: 8. Mai 2019

© 2019 Biczok et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: Apart from known hereditary syndromes, the prognostic role of a history of previous unrelated tumor in meningioma patients is yet unclear. Therefore, we investigated the incidence and clinical course of WHO grade I meningiomas focusing on the impact of history of unrelated tumor on recurrence.

Methods: All consecutive patients with meningioma WHO grade I receiving a gross total resection between 01/2009 and 03/2016 were included. History of an unrelated tumor was recorded. Reference point of the study was the date of surgery. Date of last follow up was 11/2018. Study endpoint was the date of tumor progression/recurrence on MRI imaging. Prognostic factors were obtained from multivariate proportional hazard models.

Results: 456 patients, including 333 women and 123 men with a median age of 57 years (range: 21–89 years) underwent complete microsurgical resection of a meningioma WHO grade I. 50 patients had a tumor not related to the meningioma. We identified 21 female patients with breast cancer, 4 patients with ovarian cancer, 4 patients with thyroid cancer, 4 patients with myoma and 17 patients with other tumor entities. 6 patients suffered from progression of the previous diagnosed unrelated tumor, 3 patients died due to tumorrelated complications during the follow-up period. The following covariates were included in the statistical model: age, sex, clinical history of unrelated tumor, location (skull base vs. convexity) and presence of bone invasion. However, clinical history of an unrelated tumor was the most significant predictor of tumor recurrence (p=0.003, HR: 3.25). While 9/50 (18%) patients with a medical history of an unrelated tumor developed tumor recurrence, only 34/407 (8.4%) patients without such history did so.

Conclusion: Among patients with meningiomas classified as grade I, history of any other unrelated tumor is a rare event. Such patients are more likely to experience tumor recurrence. A detailed presurgical history of unrelated tumors is important to identify patients at risk.