gms | German Medical Science

70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12.05. - 15.05.2019, Würzburg

Functional connectivity of the cerebellum – a neurosurgical perspective

Die funktionelle Konnektivität des Zerebellums – eine neurochirurgische Perspektive

Meeting Abstract

Suche in Medline nach

  • presenting/speaker Thomas Beez - Medizinische Fakultät, Heinrich-Heine-Universität, Klinik für Neurochirurgie, Düsseldorf, Deutschland
  • Hans-Jakob Steiger - Medizinische Fakultät, Heinrich-Heine-Universität, Klinik für Neurochirurgie, Düsseldorf, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocV175

doi: 10.3205/19dgnc202, urn:nbn:de:0183-19dgnc2027

Veröffentlicht: 8. Mai 2019

© 2019 Beez et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: Although a frequent localization of pediatric brain tumors, little is known concerning the functional connectivity of the cerebellum, compared to general knowledge about eloquent supratentorial brain areas. Considering the severe potential sequelae of cerebellar injury, e.g. postoperative cerebellar mutism syndrome (CMS), aim of the present study was to improve understanding of cerebellar function by systematically analyzing the modern data on connectivity of the cerebellum.

Methods: Following the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)” guidelines, a systematic literature search was performed for the terms “cerebellum” and “tractography”. Results were manually filtered for studies on healthy humans, which provided complete connectivity information of cerebellar localization, neuronal tract and extracerebellar localization.

Results: From 162 records, ultimately 25 were included in the analysis, providing magnetic resonance imaging (MRI) tractography and/or functional MRI data for 1,917 patients with an age range from 30 gestational weeks to 87 years. Fifteen studies reported sensorimotor connectivity, with the anterior and posterior cerebellar lobes, the middle and superior cerebellar peduncles (MCP, SCP) and the primary motor cortex being the main pathway. Cognitive, associative and limbic connectivity was described in 14 studies, with the posterior vermis and crus I/II, the MCP and SCP and frontal, parietal, temporal and limbic cerebral areas being the main pathways. Additionally, the dentate nucleus, pons, red nucleus, inferior olivary nucleus and thalamic nuclei are involved in these cerebro-ponto-cerebellar and cerebro-olivo-cerebellar connections.

Conclusion: This study provides a comprehensive analysis of the literature on functional connectivity of the cerebellum. Involvement in sensorimotor function, but also in cognitive, associative and limbic functions explains the complex and widely scattered symptoms found in CMS. In addition to the cerebellar cortex, the dentate nucleus, MCP and SCP are major posterior fossa structures involved in cerebellar connectivity, and thus might provide the key to understanding and avoiding CMS.