gms | German Medical Science

70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12.05. - 15.05.2019, Würzburg

Subtype-specific communication between subdivision of the STN and different motor cortical areas in tremor and non-tremor PD patients

Subtypen-spezifische Kommunikation zwischen dem STN und unterschiedlichen motorischen Arealen bei Tremor-dominanten und aklinetischem M. Parkinson

Meeting Abstract

Suche in Medline nach

  • presenting/speaker Georgios Naros - Eberhard-Karls-Universität, Klinik für Neurochirurgie, Tübingen, Deutschland; Eberhard-Karls-Universität, Sektion für funktionelle und restaurative Neurochirurgie, Tübingen, Deutschland
  • Florian Grimm - Eberhard-Karls-Universität, Klinik für Neurochirurgie, Tübingen, Deutschland; Eberhard-Karls-Universität, Sektion für funktionelle und restaurative Neurochirurgie, Tübingen, Deutschland
  • Daniel Weiß - Eberhard-Karls-Universität, Neurologie mit Schwerpunkt Neurodegenerative Erkrankungen, Tübingen, Deutschland
  • Alireza Gharabaghi - Eberhard-Karls-Universität, Klinik für Neurochirurgie, Tübingen, Deutschland; Eberhard-Karls-Universität, Sektion für funktionelle und restaurative Neurochirurgie, Tübingen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocV090

doi: 10.3205/19dgnc105, urn:nbn:de:0183-19dgnc1057

Veröffentlicht: 8. Mai 2019

© 2019 Naros et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: There is recent evidence that different PD subtypes are characterized by distinct directional information flow between cortex, subthalamic nucleus (STN) and upper limb muscles within distinct carrier frequencies. However, the spatial dissemination of these directional networks on the cortex and within the STN remains unclear. The objective of this study was the spectral and spatial dissection of subtype-specific directional PD networks within the cortical motor system and the STN.

Methods: Multiple local-field potentials of the STN as well as electromyographic and electroencephalographic rhythms were recorded in twenty tremor-dominant and non-tremor PD patients during DBS surgery. Resting-state effective connectivity between these electrophysiological signals was analyzed and compared to patient’s tremor and non-tremor motor symptoms.

Results: Effective connectivity analysis revealed a spatial distinction of different directional networks within five different carrier frequencies. Non-tremor PD symptoms were associated with an increased communication within low (15-25 Hz) and high beta (25-35 Hz) frequencies between the dorsoanterior STN (daSTN) and mesial cortical motor system (i.e. SMA). In contrast, there was an intensified information flow between the ventroposterior STN (vpSTN), the lateral cortical motor system (i.e. M1) and the muscle in the single (4-8 Hz) and double tremor (8-15 Hz) frequencies in tremor-dominant patients. There were no significant subtype-specific differences in the γ-frequency (35-45 Hz).

Conclusion: Our results confirm spectrally and spatially distinct directional networks in PD subtypes which can be disentangled by local-field recording during deep brain surgery. This knowledge could help to improve DBS targeting and therapy in different PD phenotypes.