Artikel
Is a circumscribed lesion-oriented resection of focal cortical dysplasia sufficient?
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Veröffentlicht: | 18. Juni 2018 |
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Gliederung
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Objective: Complete resection of the lesion is the goal of epilepsy surgery in imaging-positive focal cortical dysplasia (FCD), since incomplete resection has proven to be a negative predictor of seizure outcome. Recently, super-selective strategies of circumscribed lesion-oriented resections have been suggested. The aim of this study is to investigate reasons of failed epilepsy surgery in patients in whom a circumscribed FCD has been resected completely.
Methods: In a database of more than 250 consecutive surgical cases with focal cortical dysplasia and medically refractory epilepsy, we searched for patients who were not seizure-free postoperatively. We retrospectively reviewed and evaluated the pre- and postoperative magnetic resonance imaging (MRI) as well as the neuro-navigation based resection plans.
Results: Seven not seizure-free patients (6 males/1 female) with the mean age of 28 years (range 18-37) were identified. Six patients received frontal resections (5 right/1 left) and one patient left occipital resection. Histological examination per ILAE criteria revealed FCD IIa in 5 and IIb in 2 cases. In all patients, the resection plan on the neuro-navigation system was delimited to the visible borders of the lesion. The postoperative MRI showed a complete resection of the visible lesion in all cases. Despite complete resection of the lesion, seizures persisted in this subgroup of patients.
Conclusion: As shown in these cases, a purely lesion-oriented circumscribed resection of FCD may be insufficient to achieve seizure freedom. Further electrophysiological evaluation of these cases with intraoperative or long-term intracranial recordings is mandatory to define the extent of the epileptogenic area.