gms | German Medical Science

69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

03.06. - 06.06.2018, Münster

Is a circumscribed lesion-oriented resection of focal cortical dysplasia sufficient?

Meeting Abstract

  • Evangelos Kogias - Universitätsklinikum Freiburg, Klinik für Neurochirurgie, Freiburg, Deutschland
  • Karl Egger - Universitätsklinikum Freiburg, Klinik für Neuroradiologie, Freiburg, Deutschland
  • Julia M. Nakagawa - Universitätsklinikum Freiburg, Klinik für Neurochirurgie, Freiburg, Deutschland
  • Christian Scheiwe - Universitätsklinikum Freiburg, Klinik für Neurochirurgie, Freiburg, Deutschland
  • Horst Urbach - Universitätsklinikum Freiburg, Klinik für Neuroradiologie, Freiburg, Deutschland
  • Josef Zentner - Universitätsklinikum Freiburg, Klinik für Neurochirurgie, Freiburg, Deutschland
  • Andreas Schulze-Bonhage - Universitätsklinikum Freiburg, Epilepsiezentrum, Freiburg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie. Münster, 03.-06.06.2018. Düsseldorf: German Medical Science GMS Publishing House; 2018. DocP198

doi: 10.3205/18dgnc539, urn:nbn:de:0183-18dgnc5399

Veröffentlicht: 18. Juni 2018

© 2018 Kogias et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: Complete resection of the lesion is the goal of epilepsy surgery in imaging-positive focal cortical dysplasia (FCD), since incomplete resection has proven to be a negative predictor of seizure outcome. Recently, super-selective strategies of circumscribed lesion-oriented resections have been suggested. The aim of this study is to investigate reasons of failed epilepsy surgery in patients in whom a circumscribed FCD has been resected completely.

Methods: In a database of more than 250 consecutive surgical cases with focal cortical dysplasia and medically refractory epilepsy, we searched for patients who were not seizure-free postoperatively. We retrospectively reviewed and evaluated the pre- and postoperative magnetic resonance imaging (MRI) as well as the neuro-navigation based resection plans.

Results: Seven not seizure-free patients (6 males/1 female) with the mean age of 28 years (range 18-37) were identified. Six patients received frontal resections (5 right/1 left) and one patient left occipital resection. Histological examination per ILAE criteria revealed FCD IIa in 5 and IIb in 2 cases. In all patients, the resection plan on the neuro-navigation system was delimited to the visible borders of the lesion. The postoperative MRI showed a complete resection of the visible lesion in all cases. Despite complete resection of the lesion, seizures persisted in this subgroup of patients.

Conclusion: As shown in these cases, a purely lesion-oriented circumscribed resection of FCD may be insufficient to achieve seizure freedom. Further electrophysiological evaluation of these cases with intraoperative or long-term intracranial recordings is mandatory to define the extent of the epileptogenic area.