Artikel
Genome-wide association analysis identifies a meningioma risk locus at 11p15.5
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Autoren
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Matthias Simon
- Evangelisches Klinikum Bethel, Neurochirurgie, Bielefeld, Deutschland
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Elisabeth B. Claus
- Yale University, School of Public Health, New Haven, CT, Vereinigte Staaten; Brigham and Women's Hospital, Dept. of Neurosurgery, Boston, MA, Vereinigte Staaten
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Alex J. Cornish
- The Institute of Cancer Research, Division of Genetics and Epidemiology, London, Vereinigtes Königreich
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Sara E. Dobbins
- The Institute of Cancer Research, Division of Genetics and Epidemiology, London, Vereinigtes Königreich
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Joellen M. Schildkraut
- University of Virginia, Department of Public Health Sciences, Charlottesville, VA, Vereinigte Staaten
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Melissa Bondy
- Baylor College of Medicine, Section of Epidemiology and Population Sciences, Department of Medicine and Dan L. Duncan Comprehensive Cancer Center, Houston, TX, Vereinigte Staaten
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Margaret Wrensch
- University of California San Francisco, Department of Neurological Surgery, San Francisco, CA, Vereinigte Staaten; University of California San Francisco, Institute for Human Genetics, San Francisco, CA, Vereinigte Staaten
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Richard Houlston
- The Institute of Cancer Research, Division of Genetics and Epidemiology, London, Vereinigtes Königreich
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Joseph L. Wiemels
- University of California San Francisco, Department of Neurological Surgery, San Francisco, CA, Vereinigte Staaten; University of California San Francisco, Institute for Human Genetics, San Francisco, CA, Vereinigte Staaten; University of California San Francisco, Department of Epidemiology and Biostatistics, San Francisco, CA, Vereinigte Staaten
| Veröffentlicht: | 18. Juni 2018 |
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Gliederung
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Objective: The high incidence of meningiomas in neurofibromatosis type 2 patients provides strong evidence for an inherited predisposition to these tumors. An elevated risk of meningioma formation is also observed in several other genetic disorders. Several candidate gene polymorphisms have been investigated for associations with susceptibility to meningioma, but this approach is inherently flawed by (gene) selection bias. Genome-wide association studies (GWAS) may overcome this problem.
Methods: We performed a meta-analysis of two GWAS totaling 2,163 cases and 12,091 controls (GER-GWAS: 834 cases/250 male and 2,103 controls/1,047 male, US-GWAS: 772 cases/217 male and 7,720 controls/2,966 male) with validation in two independent sample series (UK: 443 cases and 1,862 controls, DEN: 114 cases and 406 controls).
Results: Our study confirmed the presence of a previously described risk locus at 10p12.31 (P = 1.41 x 10-11). We identified an additional genome-wide association signal with rs7124615 at 11p15.5 (P = 6.40 x 10-9) close to the RIC8A gene. RIC8A plays an essential role in the development of the mammalian central nervous system maintaining the integrity of the pial basement membrane and modulating cell division. Together, genetic variation at 10p12.31 and 11p15.5 accounts for approximately 4% of the familial risk of meningioma. Meningioma heritability associated with common genetic variation is 27.9% (±4.4%).
Conclusion: We have provided the first evidence that implicates variation at 11p15.5 close to the RIC8A gene as a determinant of meningioma risk, and thereby to a role for RIC8A dysregulation in meningioma pathogenesis. The present study is only the second and the largest meningioma GWAS conducted so far.
