Artikel
The influence of complex cytogenetic aberration patterns on recurrent meningiomas
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Autoren
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Sina Hemmer
- Universitätsklinikum des Saarlandes, Klinik für Neurochirurgie, Homburg, Deutschland
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Steffi Urbschat
- Universitätsklinikum des Saarlandes, Klinik für Neurochirurgie, Homburg, Deutschland
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Joachim Oertel
- Universitätsklinikum des Saarlandes, Klinik für Neurochirurgie, Homburg, Deutschland
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Ralf Ketter
- Universitätsklinikum des Saarlandes, Klinik für Neurochirurgie, Homburg, Deutschland
| Veröffentlicht: | 18. Juni 2018 |
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Gliederung
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Objective: Cytogenetically, meningiomas frequently harbour a normal karyotype or monosomy of chromosome 22. However, progression of meningiomas is associated with a non-random pattern of secondary losses of other autosomes. Deletions of the short arm of chromosome 1 are characteristic and specific alterations for the progression of these tumors. The aim of this study was to determine the influence of complex aberration patterns of the chromosomes 1, 10, 17 and 22 on the recurrence of meningiomas.
Methods: The authors retrospectively reviewed all patients that underwent repeated surgery for recurrent meningiomas between 1999 and 2015. Patients were included in this study if tumor samples from two or more different meningiomas were available. A total of 7 patients underwent repeated surgery for recurrent meningiomas (4 males, 3 females, mean age: 45.4 years at the date of surgery) between 1999 and 2015. Collectively, 21 biopsies were analyzed with Fluorescence-in-situ-hybridization (FISH) for the chromosomes 10, 17, 22 and the chromosomal region 1p. 200 nuclei of every tumor were analyzed.Complex aberration patterns were defined as alterations of three or four chromosomes.
Results: 61.9 % of the tumors showed complex aberration patterns. Loss of chromosome 22 was detected in 80.9% (17/21 tumors), loss of the chromosomal region 1p was detected in 46.6% (10/21 tumors), loss of chromosome 10 was detected in 28.6% (6/21) and loss of chromosome 17 was detected in 95.2% (20/21 tumors) of all specimens.
Conclusion: Recurrence of meningiomas seems to be associated with complex aberrations of the four chromosomes that were analyzed in this study. According to the literature, loss of the chromosomal region 1p and loss of chromosome 10 have the strongest influence on meningioma recurrence among the chromosomes that were analyzed in this study. Besides that, loss of chromosome 17 was detected in a high frequency among the aberration patterns of the meningiomas in this study. Therefore, loss of chromosome 17 might be a potential marker for malignancy and a higher risk for recurrence in meningiomas. This phenomenon is by the time not mentioned in the literature.
