Artikel
Feasibility and safety of intraoperative BOLD MRI cerebrovascular reactivity to evaluate extracranial-to-intracranial bypass efficacy
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Veröffentlicht: | 18. Juni 2018 |
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Gliederung
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Objective: Blood Oxygenation-Level dependent Magnetic Resonance Imaging (BOLD MRI) sequences are commonly used to investigate cerebrovascular reactivity (CVR) and have found application in predicting stroke risk in patients affected by chronic cerebrovascular steno-occlusive diseases. Their usefulness in assessing the success of revascularization procedures in such patients is also well known 1,2.
Recently, some investigations have been made on the potentials of using intraoperative BOLD MRI to obtain information on CVR3,4: the feasibility of this technique during revascularization procedures and especially in patients undergoing extracranial-to-intracranial bypass (EC-IC) for chronic ischemic diseases, has never been tested.
We aimed to conduct a preliminary study to investigate the feasibility and safety of intra-op BOLD MRI to assess CVR in EC-IC procedures.
Methods: Eight patients who were operated with an EC-IC bypass underwent an additional intra-operative MR scan with BOLD sequences to assess CVR with breath-holding based techniques after the performance of the anastomosis.
Results: None of the patient showed post-operative complications or radiological alterations related to prolonged anesthesia time. One patient showed hyperperfusion syndrome. CVR maps could be obtained showing qualitative variations.
Conclusion: Intra-operative BOLD MRI sequence acquisition is a safe option for patients undergoing surgery for EC-IC bypass. This technique, if further developed, could offer important information on the efficacy of a bypass.